CYLD
Gene Ontology Biological Process
- necroptotic process [IGI]
- negative regulation of NF-kappaB import into nucleus [ISO]
- negative regulation of NF-kappaB transcription factor activity [IBA, ISO]
- negative regulation of T cell differentiation [IDA]
- negative regulation of canonical Wnt signaling pathway [ISO]
- positive regulation of extrinsic apoptotic signaling pathway [IBA, ISO]
- protein K63-linked deubiquitination [IBA, ISO]
- protein deubiquitination [IMP]
- proteolysis [IBA]
- regulation of intrinsic apoptotic signaling pathway [IBA, ISO]
- regulation of microtubule cytoskeleton organization [ISO]
- regulation of mitotic cell cycle [IBA, ISO]
- ripoptosome assembly involved in necroptotic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
JUN
Gene Ontology Biological Process
- SMAD protein import into nucleus [ISO]
- SMAD protein signal transduction [ISO]
- angiogenesis [IMP, ISO]
- axon regeneration [IMP]
- cellular process [IMP]
- cellular response to calcium ion [IDA]
- cellular response to potassium ion starvation [ISO]
- leading edge cell differentiation [IMP]
- learning [ISO]
- liver development [IMP]
- membrane depolarization [ISO]
- microglial cell activation [IMP]
- monocyte differentiation [IMP]
- negative regulation by host of viral transcription [ISO]
- negative regulation of DNA binding [ISO]
- negative regulation of apoptotic process [IMP]
- negative regulation of cell proliferation [IGI]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of protein autophosphorylation [IMP]
- negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- outflow tract morphogenesis [IMP]
- positive regulation by host of viral transcription [ISO]
- positive regulation of DNA replication [ISO]
- positive regulation of Rho GTPase activity [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of fibroblast proliferation [IDA, IGI]
- positive regulation of monocyte differentiation [ISO]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of cell cycle [IMP]
- regulation of transcription, DNA-templated [IMP]
- release of cytochrome c from mitochondria [ISO]
- response to drug [IDA]
- response to muscle stretch [IDA]
- response to radiation [ISO]
- transcription from RNA polymerase II promoter [ISO]
- transcription, DNA-templated [ISO]
- transforming growth factor beta receptor signaling pathway [ISO]
Gene Ontology Molecular Function- DNA binding [IDA]
- HMG box domain binding [ISO]
- R-SMAD binding [ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- Rho GTPase activator activity [ISO]
- cAMP response element binding [ISO]
- chromatin binding [IDA]
- double-stranded DNA binding [ISO]
- enzyme binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription coactivator activity [ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [IDA, ISO]
- DNA binding [IDA]
- HMG box domain binding [ISO]
- R-SMAD binding [ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- Rho GTPase activator activity [ISO]
- cAMP response element binding [ISO]
- chromatin binding [IDA]
- double-stranded DNA binding [ISO]
- enzyme binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription coactivator activity [ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [IDA, ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
CYLD inhibits tumorigenesis and metastasis by blocking JNK/AP1 signaling at multiple levels.
CYLD has been recognized as a tumor suppressor due to its dominant genetic linkage to multiple types of epidermal tumors and a range of other cancers. The molecular mechanisms governing CYLD control of skin cancer are still unclear. Here, we showed that K14-driven epidermal expression of a patient-relevant and catalytically deficient CYLD truncated mutant (CYLD(m)) sensitized mice to skin tumor ... [more]
Throughput
- Low Throughput
Additional Notes
- source of proteins not clear
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| JUN CYLD | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 611797 |
Curated By
- BioGRID