CUL4A
Gene Ontology Biological Process
- hemopoiesis [IMP]
- negative regulation of granulocyte differentiation [IDA]
- positive regulation of G1/S transition of mitotic cell cycle [IMP]
- positive regulation of cell proliferation [IDA]
- positive regulation of protein catabolic process [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- regulation of DNA damage checkpoint [IMP]
- regulation of nucleotide-excision repair [IMP]
- regulation of protein metabolic process [IMP]
- somatic stem cell maintenance [IMP]
- ubiquitin-dependent protein catabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RBX1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1.
The Elongin complex stimulates the rate of transcription elongation by RNA polymerase II (pol II) by suppressing transient pausing of the pol II at many sites along the DNA. Elongin is composed of a transcriptionally active A subunit and two small regulatory B and C subunits, which can form an isolable Elongin BC subcomplex. Here, we have shown that both ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RBX1 CUL4A | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.94 | BioGRID | 2662696 |
Curated By
- BioGRID