BAIT
ELP2
KTI3, TOT2, Elongator subunit ELP2, YGR200C
Subunit of Elongator complex; Elongator is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
GO Process (3)
GO Function (0)
GO Component (3)
Gene Ontology Biological Process
Saccharomyces cerevisiae (S288c)
PREY
TE(UUC)E2
L000003795
Glutamate tRNA (tRNA-Glu), predicted by tRNAscan-SE analysis; thiolation of uridine at wobble position (34) requires Ncs6p
GO Process (1)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
Dosage Rescue
A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.
Publication
Elongator complex influences telomeric gene silencing and DNA damage response by its role in wobble uridine tRNA modification.
Elongator complex is required for formation of the side chains at position 5 of modified nucleosides 5-carbamoylmethyluridine (ncmâµU₃₄), 5-methoxycarbonylmethyluridine (mcmâµU₃₄), and 5-methoxycarbonylmethyl-2-thiouridine (mcmâµs²U₃₄) at wobble position in tRNA. These modified nucleosides are important for efficient decoding during translation. In a recent publication, Elongator complex was implicated to participate in telomeric gene silencing and DNA damage response by interacting with proliferating ... [more]
PLoS Genet. Sep. 01, 2011; 7(9);e1002258 [Pubmed: 21912530]
Throughput
- Low Throughput
Ontology Terms
- phenotype: chromosome/plasmid maintenance (APO:0000143)
- phenotype: resistance to chemicals (APO:0000087)
- phenotype: vegetative growth (APO:0000106)
- phenotype: silencing (APO:0000046)
Additional Notes
- Elevated levels of some modified tRNAs suppress the defects in telomeric silencing and DNA damage response seen in Elongator complex mutants
Curated By
- BioGRID