BAIT
SMARCAD1
ADERM, ETL1, HEL1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
GO Process (11)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- ATP-dependent chromatin remodeling [IMP]
- DNA double-strand break processing [IMP]
- chromatin modification [NAS]
- chromatin remodeling [NAS]
- chromosome separation [IMP]
- histone H3 deacetylation [IMP]
- histone H4 deacetylation [IMP]
- nucleotide metabolic process [NAS]
- positive regulation of transcription, DNA-templated [NAS]
- protein homooligomerization [NAS]
- regulation of DNA recombination [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HNRNPK
CSBP, HNRPK, TUNP, RP11-575L7.1
heterogeneous nuclear ribonucleoprotein K
GO Process (10)
GO Function (6)
GO Component (7)
Gene Ontology Biological Process
- RNA processing [TAS]
- RNA splicing [TAS]
- gene expression [TAS]
- mRNA splicing, via spliceosome [IC, TAS]
- positive regulation of low-density lipoprotein particle receptor biosynthetic process [IMP]
- positive regulation of receptor-mediated endocytosis [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of low-density lipoprotein particle clearance [IMP]
- signal transduction [TAS]
Gene Ontology Molecular Function- RNA binding [TAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- single-stranded DNA binding [TAS]
- RNA binding [TAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- single-stranded DNA binding [TAS]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.
Epigenetic marks such as posttranslational histone modifications specify the functional states of underlying DNA sequences, though how they are maintained after their disruption during DNA replication remains a critical question. We identify the mammalian SWI/SNF-like protein SMARCAD1 as a key factor required for the re-establishment of repressive chromatin. The ATPase activity of SMARCAD1 is necessary for global deacetylation of histones ... [more]
Mol. Cell May. 06, 2011; 42(3);285-96 [Pubmed: 21549307]
Throughput
- Low Throughput
Curated By
- BioGRID