BAIT
NEDD4
Nedd4a
neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
GO Process (35)
GO Function (12)
GO Component (13)
Gene Ontology Biological Process
- T cell activation [ISO]
- adaptive immune response [ISO]
- blood vessel morphogenesis [ISO]
- cellular response to UV [ISO]
- development involved in symbiotic interaction [ISO]
- endocardial cushion development [ISO]
- glucocorticoid receptor signaling pathway [ISO]
- immune response [IEP]
- lysosomal transport [ISO]
- negative regulation of sodium ion transport [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage [ISO]
- negative regulation of vascular endothelial growth factor receptor signaling pathway [ISO, ISS]
- neuromuscular junction development [ISO]
- neuron projection development [ISO]
- outflow tract morphogenesis [ISO]
- positive regulation of nucleocytoplasmic transport [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of protein catabolic process [ISO]
- progesterone receptor signaling pathway [ISO]
- protein K63-linked ubiquitination [IDA]
- protein monoubiquitination [ISO]
- protein targeting to lysosome [ISO]
- protein ubiquitination [ISO, ISS]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA, ISO]
- receptor catabolic process [ISO]
- receptor internalization [ISO]
- regulation of dendrite morphogenesis [IDA, ISO]
- regulation of ion transmembrane transport [ISO]
- regulation of membrane potential [ISO]
- regulation of potassium ion transmembrane transporter activity [ISO]
- regulation of synapse organization [ISO]
- response to denervation involved in regulation of muscle adaptation [IEP]
- transmission of virus [ISO]
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [ISO]
Gene Ontology Molecular Function- RNA polymerase binding [ISO]
- beta-2 adrenergic receptor binding [ISO]
- phosphoserine binding [ISO]
- phosphothreonine binding [ISO]
- proline-rich region binding [ISO]
- protein C-terminus binding [IDA, IPI]
- protein binding [IPI]
- protein domain specific binding [ISO]
- sodium channel inhibitor activity [ISO]
- ubiquitin binding [ISO]
- ubiquitin protein ligase activity [ISO]
- ubiquitin-protein transferase activity [IDA, ISO]
- RNA polymerase binding [ISO]
- beta-2 adrenergic receptor binding [ISO]
- phosphoserine binding [ISO]
- phosphothreonine binding [ISO]
- proline-rich region binding [ISO]
- protein C-terminus binding [IDA, IPI]
- protein binding [IPI]
- protein domain specific binding [ISO]
- sodium channel inhibitor activity [ISO]
- ubiquitin binding [ISO]
- ubiquitin protein ligase activity [ISO]
- ubiquitin-protein transferase activity [IDA, ISO]
Gene Ontology Cellular Component
Rattus norvegicus
PREY
KCNAB1
AKR6A3, KCNA1B, KV-BETA-1, Kvb1.3, hKvBeta3, hKvb3
potassium voltage-gated channel, shaker-related subfamily, beta member 1
GO Process (2)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays.
Target recognition by the ubiquitin system is mediated by E3 ubiquitin ligases. Nedd4 family members are E3 ligases comprised of a C2 domain, 2-4 WW domains that bind PY motifs (L/PPxY) and a ubiquitin ligase HECT domain. The nine Nedd4 family proteins in mammals include two close relatives: Nedd4 (Nedd4-1) and Nedd4L (Nedd4-2), but their global substrate recognition or differences ... [more]
Mol. Syst. Biol. Dec. 03, 2009; 5(0);333 [Pubmed: 19953087]
Throughput
- High Throughput
Additional Notes
- High Throughput: Protein microarray
Curated By
- BioGRID