ACVR1B
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [ISO]
- activin receptor signaling pathway [ISO]
- central nervous system development [IEP]
- development of primary female sexual characteristics [IEP]
- extrinsic apoptotic signaling pathway [ISO]
- hair follicle development [ISO]
- in utero embryonic development [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of gene expression [ISO]
- nodal signaling pathway [ISO]
- peptidyl-threonine phosphorylation [ISO]
- positive regulation of activin receptor signaling pathway [ISO]
- positive regulation of erythrocyte differentiation [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of trophoblast cell migration [ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [IMP, ISO, TAS]
- regulation of signal transduction [ISO]
- regulation of transcription, DNA-templated [ISO]
- signal transduction [ISO]
- signal transduction by phosphorylation [IMP]
Gene Ontology Molecular Function- ATP binding [ISO]
- SMAD binding [IMP, ISO]
- activin binding [ISO]
- activin receptor activity, type I [IMP, ISO, TAS]
- activin-activated receptor activity [ISO]
- growth factor binding [ISO]
- inhibin binding [ISO]
- protein serine/threonine kinase activity [ISO]
- receptor signaling protein serine/threonine kinase activity [IMP]
- transmembrane receptor protein serine/threonine kinase activity [TAS]
- ATP binding [ISO]
- SMAD binding [IMP, ISO]
- activin binding [ISO]
- activin receptor activity, type I [IMP, ISO, TAS]
- activin-activated receptor activity [ISO]
- growth factor binding [ISO]
- inhibin binding [ISO]
- protein serine/threonine kinase activity [ISO]
- receptor signaling protein serine/threonine kinase activity [IMP]
- transmembrane receptor protein serine/threonine kinase activity [TAS]
Gene Ontology Cellular Component
NEDD4L
Gene Ontology Biological Process
- cellular sodium ion homeostasis [NAS]
- excretion [NAS]
- gene expression [TAS]
- ion transmembrane transport [TAS]
- negative regulation of potassium ion transmembrane transport [IDA]
- negative regulation of potassium ion transmembrane transporter activity [IDA]
- negative regulation of protein localization to cell surface [IDA]
- negative regulation of sodium ion transmembrane transport [IDA]
- negative regulation of sodium ion transmembrane transporter activity [IDA]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- positive regulation of caveolin-mediated endocytosis [ISS]
- positive regulation of endocytosis [NAS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein K48-linked ubiquitination [IDA]
- protein ubiquitination [IDA, NAS]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA, IDA]
- regulation of ion transmembrane transport [IDA]
- regulation of membrane depolarization [IDA]
- regulation of membrane potential [IDA]
- regulation of membrane repolarization [IDA]
- regulation of potassium ion transmembrane transporter activity [IDA]
- regulation of protein catabolic process [NAS]
- response to metal ion [IDA]
- sodium ion transport [NAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
- transmembrane transport [TAS]
- ventricular cardiac muscle cell action potential [ISS]
- viral life cycle [TAS]
- viral process [TAS]
- water homeostasis [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays.
Target recognition by the ubiquitin system is mediated by E3 ubiquitin ligases. Nedd4 family members are E3 ligases comprised of a C2 domain, 2-4 WW domains that bind PY motifs (L/PPxY) and a ubiquitin ligase HECT domain. The nine Nedd4 family proteins in mammals include two close relatives: Nedd4 (Nedd4-1) and Nedd4L (Nedd4-2), but their global substrate recognition or differences ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID