BAIT

SREK1

SFRS12, SRrp508, SRrp86
splicing regulatory glutamine/lysine-rich protein 1
GO Process (0)
GO Function (1)
GO Component (1)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

SH3GLB2

PP6569, PP9455, RRIG1, RP11-167N5.3
SH3-domain GRB2-like endophilin B2
GO Process (0)
GO Function (1)
GO Component (3)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Regulation of alternative splicing by SRrp86 and its interacting proteins.

Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG

SRrp86 is a unique member of the SR protein superfamily containing one RNA recognition motif and two serine-arginine (SR)-rich domains separated by an unusual glutamic acid-lysine (EK)-rich region. Previously, we showed that SRrp86 could regulate alternative splicing by both positively and negatively modulating the activity of other SR proteins and that the unique EK domain could inhibit both constitutive and ... [more]

Mol. Cell. Biol. Nov. 01, 2003; 23(21);7437-47 [Pubmed: 14559993]

Throughput

  • Low Throughput

Curated By

  • BioGRID