PIM1
Gene Ontology Biological Process
- cellular response to oxidative stress [IBA]
- chaperone-mediated protein complex assembly [IGI]
- misfolded or incompletely synthesized protein catabolic process [IGI, IMP]
- mitochondrion organization [IBA]
- oxidation-dependent protein catabolic process [IBA]
- protein homooligomerization [IBA]
- response to hypoxia [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CRD1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
The conserved GTPase Gem1 regulates endoplasmic reticulum-mitochondria connections.
Mitochondria are connected to the endoplasmic reticulum (ER) through specialized protein complexes. We recently identified the ER-mitochondria encounter structure (ERMES) tethering complex, which plays a role in phospholipid exchange between the two organelles. ERMES also has been implicated in the coordination of mitochondrial protein import, mitochondrial DNA replication, and mitochondrial dynamics, suggesting that these interorganelle contact sites play central regulatory ... [more]
Throughput
- High Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PIM1 CRD1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1329 | BioGRID | 2077682 |
Curated By
- BioGRID