BAIT
UBC
ubiquitin C
GO Process (2)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
MYC
RNCMYC, c-myc, mMyc
myelocytomatosis oncogene
GO Process (83)
GO Function (13)
GO Component (11)
Gene Ontology Biological Process
- B cell apoptotic process [ISO]
- DNA-templated transcription, initiation [IDA]
- G0 to G1 transition [IEP]
- MAPK cascade [ISO, ISS]
- Wnt signaling pathway [ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- amino acid transport [IMP]
- branching involved in ureteric bud morphogenesis [ISO, ISS]
- canonical Wnt signaling pathway [ISO, ISS]
- canonical Wnt signaling pathway involved in negative regulation of apoptotic process [ISO]
- canonical Wnt signaling pathway involved in positive regulation of apoptotic process [ISO]
- canonical Wnt signaling pathway involved in positive regulation of wound healing [IMP]
- cell cycle arrest [ISO]
- cell proliferation [IMP]
- cellular iron ion homeostasis [ISO, ISS]
- cellular response to DNA damage stimulus [ISO, ISS]
- cellular response to UV [ISO]
- cellular response to carbohydrate stimulus [IEP]
- cellular response to drug [ISO]
- cellular response to estrogen stimulus [IEP]
- cellular response to hydrostatic pressure [IEP]
- cellular response to interleukin-1 [IEP]
- cellular response to organic cyclic compound [IEP]
- chromatin remodeling [ISO, ISS]
- chromosome organization [ISO, ISS]
- detection of mechanical stimulus involved in sensory perception of sound [ISO]
- flavonoid metabolic process [IEP]
- fungal-type cell wall polysaccharide metabolic process [IEP]
- glucose metabolic process [IMP]
- glycoprotein metabolic process [IEP]
- hypothalamus development [IEP]
- in utero embryonic development [IEP]
- inner mitochondrial membrane organization [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage [ISO]
- lactic acid secretion [IMP]
- middle ear morphogenesis [ISO]
- negative regulation of cell death [IMP]
- negative regulation of cell division [ISO, ISS]
- negative regulation of fibroblast proliferation [ISO]
- negative regulation of gene expression [IMP]
- negative regulation of glucose import [IMP]
- negative regulation of monocyte differentiation [ISO, ISS]
- negative regulation of protein binding [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- pathogenesis [TAS]
- pigmentation [ISO]
- positive regulation of ATP biosynthetic process [IMP]
- positive regulation of B cell apoptotic process [ISO]
- positive regulation of DNA biosynthetic process [ISO, ISS]
- positive regulation of apoptotic signaling pathway [ISO]
- positive regulation of catalytic activity [ISO]
- positive regulation of cell cycle [IMP]
- positive regulation of cell proliferation [IGI, ISO]
- positive regulation of cellular respiration [IMP]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO, ISS]
- positive regulation of epithelial cell proliferation [ISO, ISS]
- positive regulation of fibroblast proliferation [IMP, ISO, ISS]
- positive regulation of glycolytic process [IMP]
- positive regulation of mesenchymal cell proliferation [ISO, ISS]
- positive regulation of metanephric cap mesenchymal cell proliferation [ISO, ISS]
- positive regulation of mitochondrial membrane potential [IMP]
- positive regulation of response to DNA damage stimulus [ISO, ISS]
- positive regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO, ISS]
- protein processing [ISO]
- pyruvate transport [IMP]
- regulation of apoptotic process [ISO]
- regulation of gene expression [ISO]
- regulation of mitotic cell cycle [IMP]
- regulation of oxidative phosphorylation [IMP]
- regulation of telomere maintenance [ISO, ISS]
- regulation of transcription, DNA-templated [IDA, IMP, ISO, TAS]
- response to alkaloid [ISO]
- response to drug [ISO]
- response to estradiol [IEP]
- response to gamma radiation [ISO, ISS]
- response to radiation [ISO]
- response to wounding [IEP]
- skeletal muscle cell differentiation [ISO]
- skeletal system morphogenesis [ISO]
- transcription from RNA polymerase II promoter [IDA]
- transcription, DNA-templated [IDA]
- transformation of host cell by virus [IMP]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- E-box binding [ISO, ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- core promoter proximal region sequence-specific DNA binding [ISO]
- double-stranded DNA binding [IDA]
- protein binding [IPI]
- protein complex binding [ISO, ISS]
- protein heterodimerization activity [IPI]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, IMP, ISO]
- transcription factor binding [ISO]
- DNA binding [IDA, ISO]
- E-box binding [ISO, ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- core promoter proximal region sequence-specific DNA binding [ISO]
- double-stranded DNA binding [IDA]
- protein binding [IPI]
- protein complex binding [ISO, ISS]
- protein heterodimerization activity [IPI]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, IMP, ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
- axon [ISO]
- cytoplasm [IDA]
- intracellular [ISO]
- mitochondrion [IMP]
- nuclear body [ISO]
- nuclear euchromatin [ISO]
- nucleolus [IDA, ISO, ISS]
- nucleoplasm [ISO, ISS]
- nucleus [IDA, ISO, TAS]
- protein complex [ISO]
- spindle [ISO]
Rattus norvegicus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Repeated electroconvulsive seizure induces c-Myc down-regulation and Bad inactivation in the rat frontal cortex.
Repeated electroconvulsive seizure (ECS), a model for electroconvulsive therapy (ECT), exerts neuroprotective and proliferative effects in the brain. This trophic action of ECS requires inhibition of apoptotic activity, in addition to activation of survival signals. c-Myc plays an important role in apoptosis of neurons, in cooperation with the Bcl-2 family proteins, and its activity and stability are regulated by phosphorylation ... [more]
Exp. Mol. Med. Aug. 31, 2008; 40(4);435-44 [Pubmed: 18779656]
Throughput
- Low Throughput
Curated By
- BioGRID