IML3
Gene Ontology Biological Process
Gene Ontology Cellular Component
ECO1
Gene Ontology Biological Process
- DNA repair [IDA]
- DNA replication [IMP]
- chromosome organization [IMP]
- double-strand break repair [IMP]
- establishment of mitotic sister chromatid cohesion [IGI, IMP]
- internal peptidyl-lysine acetylation [IDA]
- mitotic chromosome condensation [IMP]
- regulation of DNA replication [IGI]
- regulation of mitosis [IMP]
- tRNA gene clustering [IMP]
- telomere organization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Iron-responsive Transcription Factor Aft1 Interacts with Kinetochore Protein Iml3 and Promotes Pericentromeric Cohesin.
The Saccharomyces cerevisiae iron-responsive transcription factor, Aft1, has a well established role in regulating iron homeostasis through the transcriptional induction of iron-regulon genes. However, recent studies have implicated Aft1 in other cellular processes independent of iron regulation such as chromosome stability. In addition, chromosome spreads and two-hybrid data suggest that Aft1 interacts with and co-localizes with kinetochore proteins; however, the ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- iml3 eco1-203 double mutant
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
ECO1 IML3 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.268 | BioGRID | 1980121 |
Curated By
- BioGRID