NTRK1
Gene Ontology Biological Process
- B cell differentiation [ISO]
- Sertoli cell development [IMP]
- aging [IEP]
- axon guidance [IMP]
- axonogenesis involved in innervation [ISO, ISS]
- cellular response to growth factor stimulus [IDA]
- cellular response to nerve growth factor stimulus [IDA]
- cellular response to nicotine [IDA]
- detection of mechanical stimulus involved in sensory perception of pain [IMP]
- detection of temperature stimulus involved in sensory perception of pain [IMP]
- developmental programmed cell death [IDA]
- learning or memory [IMP]
- mechanoreceptor differentiation [ISO]
- negative regulation of cell proliferation [ISO, ISS]
- negative regulation of neuron apoptotic process [IMP, ISO]
- negative regulation of neuron death [IDA]
- nerve growth factor signaling pathway [IDA, ISO]
- nervous system development [ISO]
- neurotrophin TRK receptor signaling pathway [ISO, ISS]
- olfactory nerve development [IEP]
- peptidyl-tyrosine phosphorylation [IDA, ISO, ISS]
- positive regulation of ERK1 and ERK2 cascade [ISO, ISS]
- positive regulation of NF-kappaB transcription factor activity [ISO, ISS]
- positive regulation of Ras GTPase activity [ISO, ISS]
- positive regulation of Ras protein signal transduction [ISO, ISS]
- positive regulation of angiogenesis [ISO]
- positive regulation of neuron projection development [ISO, ISS]
- positive regulation of programmed cell death [IDA]
- positive regulation of synaptic transmission, glutamatergic [IMP]
- protein autophosphorylation [IDA, ISO]
- protein phosphorylation [ISO, ISS]
- response to activity [IDA]
- response to axon injury [IEP]
- response to drug [IDA]
- response to electrical stimulus [IDA]
- response to ethanol [IEP]
- response to hydrostatic pressure [IEP]
- response to nicotine [IDA]
- response to nutrient levels [IDA]
- response to radiation [IEP]
- sensory perception of pain [IMP]
- sympathetic nervous system development [ISO, ISS]
Gene Ontology Molecular Function- ephrin receptor binding [IPI]
- kinase binding [IPI]
- nerve growth factor binding [IDA, ISO, ISS]
- nerve growth factor receptor activity [ISO, ISS]
- neurotrophin p75 receptor binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [ISO, ISS]
- protein tyrosine kinase activity [IDA]
- transmembrane receptor protein tyrosine kinase activity [ISO, ISS]
- ephrin receptor binding [IPI]
- kinase binding [IPI]
- nerve growth factor binding [IDA, ISO, ISS]
- nerve growth factor receptor activity [ISO, ISS]
- neurotrophin p75 receptor binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [ISO, ISS]
- protein tyrosine kinase activity [IDA]
- transmembrane receptor protein tyrosine kinase activity [ISO, ISS]
Gene Ontology Cellular Component
UBC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
TrkA receptor endolysosomal degradation is both ubiquitin and proteasome dependent.
Gaps in our knowledge exist regarding the degradation of the tropomyosin-regulated kinase A (TrkA) receptor after addition of neurotrophin, nerve growth factor (NGF). TrkA is rapidly and transiently ubiquitinated upon addition of NGF. Here, we demonstrate that the polyubiquitin tag plays a definitive role in receptor sorting. Treatment of PC12 cells with lactacystin prevented NGF-dependent deubiquitination and degradation of TrkA. ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID