CASP6
Gene Ontology Biological Process
- acute inflammatory response to non-antigenic stimulus [ISO]
- apoptotic process [IBA]
- positive regulation of apoptotic process [ISO]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of retinal cell programmed cell death [ISO]
- proteolysis [IBA, ISO]
- response to cytokine [ISO]
- response to glucose [ISO]
- response to hydrogen peroxide [ISO]
- response to iron ion [ISO]
Gene Ontology Molecular Function
IRAK3
Gene Ontology Biological Process
- cytokine-mediated signaling pathway [IDA]
- interleukin-1-mediated signaling pathway [IDA, ISO]
- negative regulation of MAP kinase activity [IMP, ISO]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of cytokine-mediated signaling pathway [IC]
- negative regulation of innate immune response [IMP]
- negative regulation of interleukin-12 production [IMP, ISO]
- negative regulation of interleukin-6 production [IMP, ISO]
- negative regulation of macrophage cytokine production [IMP]
- negative regulation of protein catabolic process [IMP, ISO]
- negative regulation of protein complex disassembly [ISO]
- negative regulation of toll-like receptor signaling pathway [IMP]
- negative regulation of tumor necrosis factor production [IMP, ISO]
- positive regulation of NF-kappaB transcription factor activity [IDA, ISO]
- positive regulation of macrophage tolerance induction [IMP]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA, ISO]
- regulation of protein complex disassembly [IDA]
- response to exogenous dsRNA [IMP]
- response to interleukin-1 [ISO]
- response to lipopolysaccharide [IMP]
- response to peptidoglycan [IMP]
- response to virus [IC]
Gene Ontology Molecular Function
Biochemical Activity (Proteolytic Processing)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Neutrophils activate alveolar macrophages by producing caspase-6-mediated cleavage of IL-1 receptor-associated kinase-M.
Alveolar macrophages (AMs) are exposed to respirable microbial particles. Similar to phagocytes in the gastrointestinal tract, AMs can suppress inflammation after exposure to nonpathogenic organisms. IL-1R-associated kinase-M (IRAK-M) is one inhibitor of innate immunity, normally suppressing pulmonary inflammation. During pneumonia, polymorphonuclear neutrophils (PMNs) are recruited by chemotactic factors released by AMs to produce an intense inflammation. We report that intact ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CASP6 IRAK3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| CASP6 IRAK3 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.871 | BioGRID | 2681484 |
Curated By
- BioGRID