UBC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FOXO1
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- cellular glucose homeostasis [ISS]
- cellular response to DNA damage stimulus [ISS]
- cellular response to cold [ISS]
- cellular response to hyperoxia [IDA]
- cellular response to insulin stimulus [ISS]
- cellular response to nitric oxide [ISS]
- cellular response to oxidative stress [ISS]
- cellular response to starvation [IDA, ISS]
- endocrine pancreas development [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fat cell differentiation [ISS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [ISS]
- negative regulation of apoptotic process [IDA]
- negative regulation of fat cell differentiation [ISS]
- negative regulation of stress-activated MAPK cascade [IDA]
- negative regulation of transcription, DNA-templated [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of apoptotic process [IMP]
- positive regulation of autophagy [IMP]
- positive regulation of protein catabolic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein acetylation [ISS]
- regulation of energy homeostasis [ISS]
- temperature homeostasis [ISS]
- transcription from RNA polymerase II promoter [IBA]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Bidirectional regulation of upstream IGF-I/insulin receptor signaling and downstream FOXO1 in cardiomyocytes.
Signaling pathways of IGF-I and insulin receptors play important roles in the regulation of myocardial function. FOXO1 is a member of the forkhead transcriptional factor family, but how insulin and IGF-I receptor signaling regulate FOXO1 in cardiomyocytes is not well understood. This study was carried out to elucidate how IGF-I and insulin receptor signaling modulate FOXO1 in cardiomyocytes. In cardiomyocytes, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID