CD4
Gene Ontology Biological Process
- T cell costimulation [TAS]
- T cell differentiation [IDA]
- T cell receptor signaling pathway [TAS]
- T cell selection [IDA]
- cell surface receptor signaling pathway [TAS]
- entry into host cell [TAS]
- enzyme linked receptor protein signaling pathway [TAS]
- immune response [NAS]
- induction by virus of host cell-cell fusion [IDA]
- innate immune response [TAS]
- maintenance of protein location in cell [IDA]
- positive regulation of interleukin-2 biosynthetic process [NAS]
- positive regulation of protein kinase activity [IDA]
- protein palmitoleylation [IDA]
- regulation of T cell activation [IDA]
- regulation of defense response to virus by virus [TAS]
- signal transduction [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [NAS]
- viral process [TAS]
Gene Ontology Molecular Function- MHC class II protein binding [NAS]
- coreceptor activity [NAS]
- enzyme binding [IPI]
- extracellular matrix structural constituent [NAS]
- glycoprotein binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase binding [IPI]
- receptor activity [TAS]
- transmembrane signaling receptor activity [TAS]
- zinc ion binding [IDA]
- MHC class II protein binding [NAS]
- coreceptor activity [NAS]
- enzyme binding [IPI]
- extracellular matrix structural constituent [NAS]
- glycoprotein binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase binding [IPI]
- receptor activity [TAS]
- transmembrane signaling receptor activity [TAS]
- zinc ion binding [IDA]
Gene Ontology Cellular Component
NR3C1
Gene Ontology Biological Process
- cellular response to steroid hormone stimulus [IDA]
- gene expression [TAS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [IDA]
- signal transduction [TAS]
- transcription from RNA polymerase II promoter [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- glucocorticoid receptor activity [TAS]
- glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- steroid binding [IDA]
- steroid hormone binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- glucocorticoid receptor activity [TAS]
- glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- steroid binding [IDA]
- steroid hormone binding [IDA]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN.
Although glucocorticoid (GC)-induced nongenomic effects have been reported, the underlying mechanisms remain unexplained. We previously described that lymphocyte-specific protein tyrosine kinase (LCK) and FYN oncogene related to SRC, FGR, YES (FYN) mediate GC-induced inhibition of T-cell-receptor (TCR) signalling. Here we characterize the underlying molecular mechanism. The present study shows that the GC receptor is part of a TCR-linked multiprotein complex ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NR3C1 CD4 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID