TNNI3
Gene Ontology Biological Process
- cardiac muscle contraction [ISO]
- cellular calcium ion homeostasis [IDA, IMP]
- heart contraction [ISO]
- heart development [IDA]
- negative regulation of ATPase activity [ISO]
- regulation of muscle contraction [IDA]
- regulation of smooth muscle contraction [ISO]
- regulation of systemic arterial blood pressure by ischemic conditions [IMP]
- striated muscle contraction [IDA]
- vasculogenesis [IDA]
- ventricular cardiac muscle tissue morphogenesis [ISO]
Gene Ontology Molecular Function
TNNC1
Gene Ontology Biological Process
- cardiac muscle contraction [IMP, ISO]
- diaphragm contraction [IDA]
- regulation of ATPase activity [ISO]
- regulation of muscle contraction [ISO]
- regulation of muscle filament sliding speed [ISO]
- response to metal ion [IDA]
- transition between fast and slow fiber [ISO]
- ventricular cardiac muscle tissue morphogenesis [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-crystal Structure
Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex.
Publication
The solution structure of a cardiac troponin C-troponin I-troponin T complex shows a somewhat compact troponin C interacting with an extended troponin I-troponin T component.
We have investigated the structure of the cTnC-cTnI-cTnT(198-298) calcium-saturated, ternary cardiac troponin complex by small-angle scattering with contrast variation. Shape restoration was also applied to the scattering information resulting from the deuterated cTnC subunit, the unlabeled cTnI-cTnT(198-298) subunits, and the entire complex. The experimental results and modeling indicate that cTnC adopts a partially collapsed conformation, while the cTnI-cTnT(198-298) components have ... [more]
Throughput
- Low Throughput
Additional Notes
- dimer or C-I-T trimer
- solution structure
Curated By
- BioGRID