STXBP1
Gene Ontology Biological Process
- axon target recognition [ISO]
- exocytosis [ISO]
- long term synaptic depression [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of synaptic transmission, GABAergic [ISO]
- neuromuscular synaptic transmission [ISO]
- neurotransmitter secretion [ISO]
- platelet aggregation [ISO]
- platelet degranulation [ISO]
- positive regulation of calcium ion-dependent exocytosis [ISO]
- positive regulation of exocytosis [IMP]
- protein localization to plasma membrane [ISO]
- protein stabilization [IDA]
- regulation of synaptic vesicle priming [IMP]
- synaptic vesicle maturation [ISO]
- vesicle docking involved in exocytosis [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
STX2
Gene Ontology Biological Process
- acrosome reaction [ISO]
- cell differentiation [ISO]
- digestive tract morphogenesis [IMP]
- epithelial cell differentiation [IMP]
- intracellular protein transport [IBA]
- intracellular transport [TAS]
- microvillus assembly [IDA]
- protein oligomerization [ISO]
- regulation of blood coagulation [ISO]
- regulation of cytoskeleton organization [ISO]
- response to hydroperoxide [ISO]
- synaptic vesicle fusion to presynaptic membrane [IBA]
- vesicle docking [IBA]
- vesicle fusion [TAS]
- vesicle targeting [TAS]
- vesicle-mediated transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- SNARE complex [IBA]
- basolateral plasma membrane [ISO]
- cell surface [ISO]
- cell-cell junction [ISO]
- cytoplasmic vesicle [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- integral component of membrane [IBA, TAS]
- lamellipodium [ISO]
- membrane raft [ISO]
- midbody [IDA]
- plasma membrane [IBA, ISO]
- synaptic vesicle [IBA]
- transport vesicle [IDA]
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic.
Munc-18-1 is a 67-kDa neuronal protein that binds tightly to syntaxin 1 and functions in synaptic vesicle exocytosis (Hata, Y., Slaughter, C.A., and Suedhof, T.C. (1993a) Nature 366, 347-351). We have now characterized a new Munc-18 isoform, Munc-18-2, that exhibits 63% amino acid sequence identity with Munc-18-1. Munc-18-2 is expressed in most tissues, whereas Munc-18-1 is primarily expressed in brain. ... [more]
Throughput
- Low Throughput
Additional Notes
- syntaxin 2 may possibly be syntaxin 1b
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| STX2 STXBP1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | 616237 | |
| STX2 STXBP1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | 616369 | |
| STX2 STXBP1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | 616226 |
Curated By
- BioGRID