BAIT
NTF3
HDNF, NGF-2, NGF2, NT-3, NT3
neurotrophin 3
GO Process (19)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- activation of MAPK activity [IDA]
- activation of Ras GTPase activity [IDA]
- activation of protein kinase B activity [IDA]
- cell-cell signaling [TAS]
- induction of positive chemotaxis [IDA]
- negative regulation of neuron apoptotic process [IBA]
- negative regulation of peptidyl-tyrosine phosphorylation [IDA]
- nervous system development [TAS]
- neuron projection morphogenesis [IBA]
- positive chemotaxis [IDA]
- positive regulation of actin cytoskeleton reorganization [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of receptor internalization [IDA]
- regulation of neuron differentiation [IBA]
- signal transduction [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NGFR
LNGFR, RNNGFRR, Tnfrsf16, p75, p75NTR
nerve growth factor receptor
GO Process (37)
GO Function (9)
GO Component (17)
Gene Ontology Biological Process
- axon guidance [ISO]
- cellular response to oxidative stress [IMP]
- central nervous system development [ISO]
- circadian regulation of gene expression [ISO, ISS]
- detection of temperature stimulus [ISO]
- glucose homeostasis [ISO, ISS]
- hair follicle morphogenesis [ISO]
- intracellular protein transport [ISO, ISS]
- negative regulation of cell death [IDA]
- negative regulation of fibroblast growth factor receptor signaling pathway [ISO]
- negative regulation of hair follicle development [ISO]
- negative regulation of mitochondrial depolarization [IMP]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of neuron projection development [IDA]
- nerve development [ISO]
- positive regulation of MAPK cascade [IDA]
- positive regulation of Rho protein signal transduction [IDA]
- positive regulation of apoptotic process [IMP]
- positive regulation of apoptotic signaling pathway [ISO]
- positive regulation of cell death [IDA]
- positive regulation of fibroblast proliferation [ISO]
- positive regulation of myelination [IMP]
- positive regulation of neuron death [IDA]
- positive regulation of odontogenesis of dentin-containing tooth [ISO]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of synaptic transmission, cholinergic [IMP]
- positive regulation of synaptic transmission, glutamatergic [IMP]
- programmed cell death [ISO]
- regulation of gene expression [ISO]
- regulation of glucose import in response to insulin stimulus [ISO, ISS]
- regulation of reactive oxygen species metabolic process [IMP]
- response to lipopolysaccharide [IEP]
- response to wounding [IMP]
- sensory perception of pain [IMP]
- signal transduction [IDA, ISO]
- skeletal muscle cell differentiation [IEP]
- skin development [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- cell [ISO]
- cell surface [ISO]
- clathrin-coated endocytic vesicle [IDA]
- coated vesicle [IDA]
- cytoplasm [IDA, ISO]
- dendrite membrane [IDA]
- external side of plasma membrane [IDA]
- intracellular [ISO]
- membrane raft [IDA]
- neuronal cell body membrane [IDA]
- neuronal postsynaptic density [ISO]
- nuclear envelope [IDA]
- nucleus [IDA]
- perikaryon [IDA]
- plasma membrane [IDA, ISO, TAS]
- rough endoplasmic reticulum [IDA]
Rattus norvegicus
Co-crystal Structure
Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex.
Publication
Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex.
Neurotrophins (NTs) are important regulators for the survival, differentiation and maintenance of different peripheral and central neurons. NTs bind to two distinct classes of glycosylated receptor: the p75 neurotrophin receptor (p75(NTR)) and tyrosine kinase receptors (Trks). Whereas p75(NTR) binds to all NTs, the Trk subtypes are specific for each NT. The question of whether NTs stimulate p75(NTR) by inducing receptor ... [more]
Nature Aug. 07, 2008; 454(7205);789-93 [Pubmed: 18596692]
Throughput
- Low Throughput
Additional Notes
- 2:2 complex
Related interactions
Curated By
- BioGRID