CCND1
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IDA, ISO]
- Leydig cell differentiation [ISO]
- Wnt signaling pathway [IDA]
- canonical Wnt signaling pathway [IMP]
- cellular response to DNA damage stimulus [ISO]
- cellular response to organic substance [IDA]
- endoplasmic reticulum unfolded protein response [IDA]
- fat cell differentiation [IDA]
- lactation [IGI, IMP]
- mammary gland alveolus development [IGI, IMP]
- mammary gland epithelial cell proliferation [IGI]
- mitotic G1 DNA damage checkpoint [ISO]
- negative regulation of Wnt signaling pathway [IMP]
- negative regulation of cell cycle arrest [ISO]
- negative regulation of epithelial cell differentiation [IGI]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of G2/M transition of mitotic cell cycle [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity [ISO]
- positive regulation of mammary gland epithelial cell proliferation [IGI]
- positive regulation of protein phosphorylation [ISO]
- protein phosphorylation [IDA]
- re-entry into mitotic cell cycle [IDA]
- regulation of G1/S transition of mitotic cell cycle [IGI]
- regulation of cell cycle [IDA]
- regulation of protein kinase activity [IDA]
- response to UV-A [ISO]
- response to organonitrogen compound [ISO]
Gene Ontology Molecular Function- cyclin-dependent protein serine/threonine kinase regulator activity [IDA]
- enzyme binding [ISO]
- histone deacetylase binding [ISO]
- kinase activity [IDA]
- proline-rich region binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase activity [IDA]
- protein kinase binding [IPI, ISO]
- transcription corepressor activity [ISO]
- transcription factor binding [ISO]
- cyclin-dependent protein serine/threonine kinase regulator activity [IDA]
- enzyme binding [ISO]
- histone deacetylase binding [ISO]
- kinase activity [IDA]
- proline-rich region binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase activity [IDA]
- protein kinase binding [IPI, ISO]
- transcription corepressor activity [ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
CRYAB
Gene Ontology Biological Process
- apoptotic process involved in morphogenesis [IGI]
- camera-type eye development [IGI]
- cellular response to gamma radiation [ISO]
- lens development in camera-type eye [IGI]
- microtubule polymerization or depolymerization [ISO]
- muscle organ development [IGI]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of cell growth [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IGI]
- negative regulation of gene expression [IMP]
- negative regulation of intracellular transport [ISO]
- negative regulation of reactive oxygen species metabolic process [ISO]
- protein folding [ISO]
- protein homooligomerization [ISO]
- regulation of cell death [ISO]
- response to hydrogen peroxide [IMP]
- response to hypoxia [IMP]
- stress-activated MAPK cascade [ISO]
- tubulin complex assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex.
Growth factor-dependent accumulation of the cyclin D1 proto-oncogene is balanced by its rapid phosphorylation-dependent proteolysis. Degradation is triggered by threonine 286 phosphorylation, which promotes its ubiquitination by an unknown E3 ligase. We demonstrate that Thr286-phosphorylated cyclin D1 is recognized by a Skp1-Cul1-F box (SCF) ubiquitin ligase where FBX4 and alphaB crystallin govern substrate specificity. Overexpression of FBX4 and alphaB crystallin ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CCND1 CRYAB | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID