BAIT
DMD
BMD, CMD3B, DXS142, DXS164, DXS206, DXS230, DXS239, DXS268, DXS269, DXS270, DXS272, MRX85, GS1-19O24.1
dystrophin
GO Process (22)
GO Function (8)
GO Component (14)
Gene Ontology Biological Process
- cardiac muscle cell action potential [ISS]
- cardiac muscle contraction [IMP]
- cellular protein complex assembly [ISS]
- cellular protein localization [IMP]
- extracellular matrix organization [TAS]
- motile cilium assembly [TAS]
- muscle filament sliding [TAS]
- muscle organ development [NAS]
- negative regulation of peptidyl-cysteine S-nitrosylation [ISS]
- negative regulation of peptidyl-serine phosphorylation [ISS]
- peptide biosynthetic process [IDA]
- positive regulation of neuron differentiation [IMP]
- positive regulation of neuron projection development [IMP]
- positive regulation of sodium ion transmembrane transporter activity [ISS]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [ISS]
- regulation of cellular response to growth factor stimulus [IMP]
- regulation of heart rate [IMP]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [ISS]
- regulation of ryanodine-sensitive calcium-release channel activity [ISS]
- regulation of skeletal muscle contraction [ISS]
- regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion [ISS]
- regulation of voltage-gated calcium channel activity [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- actin cytoskeleton [TAS]
- cell surface [IDA]
- costamere [IDA]
- cytosol [TAS]
- dystrophin-associated glycoprotein complex [IDA, NAS, TAS]
- filopodium [IDA]
- filopodium membrane [IDA]
- lateral plasma membrane [TAS]
- membrane raft [TAS]
- nucleus [IDA, TAS]
- plasma membrane [TAS]
- protein complex [IDA]
- sarcolemma [IDA]
- syntrophin complex [TAS]
Homo sapiens
PREY
ITGB1
integrin, beta 1
GO Process (58)
GO Function (18)
GO Component (32)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [ISO]
- axon extension [ISO]
- calcium-independent cell-matrix adhesion [ISO]
- cardiac muscle cell differentiation [ISO]
- cardiac muscle tissue development [ISO]
- cell adhesion [IDA]
- cell fate specification [ISO]
- cell migration [ISO]
- cell migration involved in sprouting angiogenesis [ISO]
- cell-cell adhesion mediated by integrin [ISO]
- cell-matrix adhesion [ISO]
- cell-substrate adhesion [ISO]
- cellular calcium ion homeostasis [IDA]
- cellular response to ionizing radiation [IEP]
- cellular response to mechanical stimulus [IEP]
- cellular response to vitamin D [IEP]
- dendrite morphogenesis [ISO]
- formation of radial glial scaffolds [ISO]
- germ cell migration [ISO]
- heterotypic cell-cell adhesion [ISO]
- in utero embryonic development [ISO]
- integrin-mediated signaling pathway [IDA, ISO]
- leukocyte cell-cell adhesion [ISO]
- leukocyte tethering or rolling [ISO]
- maternal process involved in female pregnancy [IEP]
- mesodermal cell differentiation [ISO]
- negative regulation of Rho protein signal transduction [ISO]
- negative regulation of anoikis [ISO]
- negative regulation of cell differentiation [ISO]
- negative regulation of cell projection organization [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of neuron differentiation [IMP]
- neuron projection development [ISO]
- positive regulation of MAPK cascade [IDA]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [ISO]
- positive regulation of cell-substrate adhesion [IMP]
- positive regulation of endocytosis [IMP]
- positive regulation of establishment of protein localization to plasma membrane [ISO, ISS]
- positive regulation of neuron differentiation [IMP]
- positive regulation of neuron projection development [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP]
- protein transport within lipid bilayer [IMP]
- regulation of G-protein coupled receptor protein signaling pathway [IMP]
- regulation of cell cycle [ISO]
- regulation of collagen catabolic process [ISO, ISS]
- response to activity [IEP]
- response to drug [IEP]
- response to gonadotropin [IEP]
- response to nutrient levels [IEP]
- response to transforming growth factor beta [IEP]
- sarcomere organization [ISO]
- stress fiber assembly [ISO]
- tight junction assembly [IMP]
- tissue homeostasis [IMP]
- transforming growth factor beta receptor signaling pathway [ISO]
- visual learning [ISO]
Gene Ontology Molecular Function- actin binding [IDA, ISO]
- alpha-actinin binding [IDA]
- cell adhesion molecule binding [ISO]
- collagen binding [IDA]
- collagen binding involved in cell-matrix adhesion [ISO]
- fibronectin binding [IDA]
- glycoprotein binding [IPI]
- integrin binding [IMP, IPI, ISO]
- kinase binding [IPI]
- laminin binding [IDA, IMP, ISO]
- peptide binding [IDA]
- protease binding [IPI, ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein domain specific binding [IDA]
- protein heterodimerization activity [IC, IMP, IPI, ISO]
- protein kinase binding [IPI]
- receptor binding [IPI]
- actin binding [IDA, ISO]
- alpha-actinin binding [IDA]
- cell adhesion molecule binding [ISO]
- collagen binding [IDA]
- collagen binding involved in cell-matrix adhesion [ISO]
- fibronectin binding [IDA]
- glycoprotein binding [IPI]
- integrin binding [IMP, IPI, ISO]
- kinase binding [IPI]
- laminin binding [IDA, IMP, ISO]
- peptide binding [IDA]
- protease binding [IPI, ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein domain specific binding [IDA]
- protein heterodimerization activity [IC, IMP, IPI, ISO]
- protein kinase binding [IPI]
- receptor binding [IPI]
Gene Ontology Cellular Component
- acrosomal vesicle [IDA]
- adherens junction [IDA]
- basement membrane [IDA]
- cell surface [IDA, ISO]
- cell-cell junction [IDA]
- cytoplasm [ISO]
- dendritic spine [ISO]
- external side of plasma membrane [ISO]
- extracellular vesicular exosome [ISO]
- filopodium [ISO]
- focal adhesion [IDA, ISO]
- hemidesmosome [IDA]
- integrin alpha1-beta1 complex [ISO]
- integrin alpha10-beta1 complex [ISO]
- integrin alpha11-beta1 complex [ISO]
- integrin alpha2-beta1 complex [ISO]
- integrin alpha3-beta1 complex [IDA, ISO]
- integrin alpha7-beta1 complex [ISO]
- integrin alpha9-beta1 complex [IDA]
- integrin complex [IC, IDA]
- intercalated disc [ISO]
- invadopodium membrane [ISO, ISS]
- membrane [IDA, ISO]
- membrane raft [IDA, ISO]
- myelin sheath abaxonal region [ISO]
- neuromuscular junction [ISO]
- plasma membrane [ISO, TAS]
- receptor complex [ISO]
- ruffle membrane [ISO]
- sarcolemma [ISO]
- synapse [ISO]
- synaptic membrane [ISO]
Rattus norvegicus
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Dystrophin Dp71f associates with the beta1-integrin adhesion complex to modulate PC12 cell adhesion.
Dystrophin Dp71 is the main product of the Duchenne muscular dystrophy gene in the brain; however, its function is unknown. To study the role of Dp71 in neuronal cells, we previously generated by antisense treatment PC12 neuronal cell clones with decreased Dp71 expression (antisense-Dp71 cells). PC12 cells express two different splicing isoforms of Dp71, a cytoplasmic variant called Dp71f and ... [more]
J. Mol. Biol. Oct. 06, 2006; 362(5);954-65 [Pubmed: 16935300]
Throughput
- Low Throughput
Curated By
- BioGRID