BAIT
DMD
BMD, CMD3B, DXS142, DXS164, DXS206, DXS230, DXS239, DXS268, DXS269, DXS270, DXS272, MRX85, GS1-19O24.1
dystrophin
GO Process (22)
GO Function (8)
GO Component (14)
Gene Ontology Biological Process
- cardiac muscle cell action potential [ISS]
- cardiac muscle contraction [IMP]
- cellular protein complex assembly [ISS]
- cellular protein localization [IMP]
- extracellular matrix organization [TAS]
- motile cilium assembly [TAS]
- muscle filament sliding [TAS]
- muscle organ development [NAS]
- negative regulation of peptidyl-cysteine S-nitrosylation [ISS]
- negative regulation of peptidyl-serine phosphorylation [ISS]
- peptide biosynthetic process [IDA]
- positive regulation of neuron differentiation [IMP]
- positive regulation of neuron projection development [IMP]
- positive regulation of sodium ion transmembrane transporter activity [ISS]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [ISS]
- regulation of cellular response to growth factor stimulus [IMP]
- regulation of heart rate [IMP]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [ISS]
- regulation of ryanodine-sensitive calcium-release channel activity [ISS]
- regulation of skeletal muscle contraction [ISS]
- regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion [ISS]
- regulation of voltage-gated calcium channel activity [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- actin cytoskeleton [TAS]
- cell surface [IDA]
- costamere [IDA]
- cytosol [TAS]
- dystrophin-associated glycoprotein complex [IDA, NAS, TAS]
- filopodium [IDA]
- filopodium membrane [IDA]
- lateral plasma membrane [TAS]
- membrane raft [TAS]
- nucleus [IDA, TAS]
- plasma membrane [TAS]
- protein complex [IDA]
- sarcolemma [IDA]
- syntrophin complex [TAS]
Homo sapiens
PREY
PTK2
FAK, FRNK, p125FAK
protein tyrosine kinase 2
GO Process (58)
GO Function (11)
GO Component (14)
Gene Ontology Biological Process
- JNK cascade [IMP]
- MAPK cascade [IMP]
- angiogenesis [IBA, ISO]
- blood vessel development [ISO]
- cellular chloride ion homeostasis [IMP]
- cellular response to transforming growth factor beta stimulus [ISO]
- central nervous system neuron axonogenesis [ISO]
- cytoskeleton organization [IBA]
- endothelial cell migration [ISO]
- ephrin receptor signaling pathway [ISO, ISS]
- epidermal growth factor receptor signaling pathway [IBA]
- establishment of nucleus localization [ISO]
- extracellular matrix organization [ISO]
- fat cell differentiation [IEP]
- growth hormone receptor signaling pathway [ISO]
- innate immune response [IBA]
- integrin-mediated signaling pathway [ISO, ISS]
- microtubule cytoskeleton organization [ISO]
- negative regulation of anoikis [ISO]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of axonogenesis [ISO]
- negative regulation of cell migration [IMP]
- negative regulation of cell-cell adhesion [ISO]
- negative regulation of organ growth [ISO]
- negative regulation of synapse assembly [ISO]
- neuron migration [ISO]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [ISO, ISS]
- positive regulation of cell adhesion [IMP]
- positive regulation of cell growth [IMP]
- positive regulation of cell migration [IMP, ISO]
- positive regulation of cell proliferation [ISO, ISS]
- positive regulation of glial cell proliferation [IMP]
- positive regulation of phagocytosis [IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO, ISS]
- positive regulation of protein kinase B signaling [ISO, ISS]
- positive regulation of protein kinase activity [ISO, ISS]
- positive regulation of protein phosphorylation [ISO, ISS]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO, ISS]
- positive regulation of smooth muscle cell migration [IMP]
- positive regulation of smooth muscle cell proliferation [IMP]
- positive regulation of synaptic transmission [IMP]
- positive regulation of vasodilation [IMP]
- protein autophosphorylation [ISO, ISS]
- regulation of cell adhesion mediated by integrin [ISO, ISS]
- regulation of cell proliferation [ISO, ISS]
- regulation of cell shape [ISO, ISS]
- regulation of osteoblast differentiation [ISO, ISS]
- response to arsenic-containing substance [IEP]
- response to drug [IEP]
- response to estradiol [IEP]
- response to glucose [IEP]
- response to mechanical stimulus [IEP]
- response to organic cyclic compound [IEP]
- response to organic substance [IEP]
- response to organonitrogen compound [IEP]
- transforming growth factor beta receptor signaling pathway [ISO]
- vasculogenesis [ISO]
Gene Ontology Molecular Function- JUN kinase binding [ISO]
- SH2 domain binding [ISO]
- actin binding [ISO]
- identical protein binding [IPI]
- integrin binding [IPI]
- non-membrane spanning protein tyrosine kinase activity [IBA, ISO, ISS]
- phosphatidylinositol 3-kinase binding [IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [ISO, TAS]
- JUN kinase binding [ISO]
- SH2 domain binding [ISO]
- actin binding [ISO]
- identical protein binding [IPI]
- integrin binding [IPI]
- non-membrane spanning protein tyrosine kinase activity [IBA, ISO, ISS]
- phosphatidylinositol 3-kinase binding [IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [ISO, TAS]
Gene Ontology Cellular Component
- apical plasma membrane [IDA, ISO]
- basolateral plasma membrane [IDA]
- cytoplasm [ISO]
- cytosol [ISO, ISS]
- extrinsic component of cytoplasmic side of plasma membrane [IBA]
- focal adhesion [IDA, ISO, TAS]
- intercalated disc [IDA]
- lamellipodium [ISO]
- nuclear body [IDA]
- nucleolus [IDA]
- nucleus [IDA, ISO]
- plasma membrane [ISO]
- sarcolemma [IDA]
- stress fiber [ISO]
Rattus norvegicus
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Dystrophin Dp71f associates with the beta1-integrin adhesion complex to modulate PC12 cell adhesion.
Dystrophin Dp71 is the main product of the Duchenne muscular dystrophy gene in the brain; however, its function is unknown. To study the role of Dp71 in neuronal cells, we previously generated by antisense treatment PC12 neuronal cell clones with decreased Dp71 expression (antisense-Dp71 cells). PC12 cells express two different splicing isoforms of Dp71, a cytoplasmic variant called Dp71f and ... [more]
J. Mol. Biol. Oct. 06, 2006; 362(5);954-65 [Pubmed: 16935300]
Throughput
- Low Throughput
Curated By
- BioGRID