BAIT
ADORA2A
A2aR, ADORA2, RDC8
adenosine A2a receptor
GO Process (15)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- activation of adenylate cyclase activity [TAS]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [TAS]
- apoptotic process [TAS]
- blood circulation [TAS]
- blood coagulation [TAS]
- cAMP biosynthetic process [TAS]
- cell-cell signaling [TAS]
- cellular defense response [TAS]
- central nervous system development [TAS]
- inflammatory response [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phagocytosis [TAS]
- positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway [IDA]
- sensory perception [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ACTN1
3110023F10Rik, Actn1a
actinin, alpha 1
GO Process (4)
GO Function (8)
GO Component (14)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Z disc [IDA]
- cell projection [ISO]
- cortical actin cytoskeleton [ISO]
- cortical cytoskeleton [TAS]
- cytoplasm [ISO]
- dendritic spine [ISO]
- dense core granule membrane [TAS]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- fascia adherens [IDA]
- focal adhesion [ISO, TAS]
- nucleus [ISO]
- secretory granule [NAS]
- stress fiber [IDA, ISO, TAS]
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The adenosine A2A receptor interacts with the actin-binding protein alpha-actinin.
Recently, evidence has emerged that heptaspanning membrane or G protein-coupled receptors may be linked to intracellular proteins identified as regulators of receptor anchoring and signaling. Using a yeast two-hybrid screen, we identified alpha-actinin, a major F-actin-cross-linking protein, as a binding partner for the C-terminal domain of the adenosine A2A receptor (A2AR). Colocalization, co-immunoprecipitation, and pull-down experiments showed a close and ... [more]
J. Biol. Chem. Sep. 26, 2003; 278(39);37545-52 [Pubmed: 12837758]
Throughput
- High Throughput|Low Throughput
Additional Notes
- Source of ADORA2A not clear
Curated By
- BioGRID