ADORA2A
Gene Ontology Biological Process
- activation of adenylate cyclase activity [TAS]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [TAS]
- apoptotic process [TAS]
- blood circulation [TAS]
- blood coagulation [TAS]
- cAMP biosynthetic process [TAS]
- cell-cell signaling [TAS]
- cellular defense response [TAS]
- central nervous system development [TAS]
- inflammatory response [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phagocytosis [TAS]
- positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway [IDA]
- sensory perception [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ADORA2A
Gene Ontology Biological Process
- activation of adenylate cyclase activity [TAS]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [TAS]
- apoptotic process [TAS]
- blood circulation [TAS]
- blood coagulation [TAS]
- cAMP biosynthetic process [TAS]
- cell-cell signaling [TAS]
- cellular defense response [TAS]
- central nervous system development [TAS]
- inflammatory response [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phagocytosis [TAS]
- positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway [IDA]
- sensory perception [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The adenosine A2A receptor interacts with the actin-binding protein alpha-actinin.
Recently, evidence has emerged that heptaspanning membrane or G protein-coupled receptors may be linked to intracellular proteins identified as regulators of receptor anchoring and signaling. Using a yeast two-hybrid screen, we identified alpha-actinin, a major F-actin-cross-linking protein, as a binding partner for the C-terminal domain of the adenosine A2A receptor (A2AR). Colocalization, co-immunoprecipitation, and pull-down experiments showed a close and ... [more]
Throughput
- Low Throughput
Additional Notes
- Source of ADORA2A not clear
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ADORA2A ADORA2A | FRET FRET An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID