CREB1
Gene Ontology Biological Process
- Type I pneumocyte differentiation [ISO]
- axonogenesis [ISO]
- cellular response to growth factor stimulus [ISO]
- cellular response to zinc ion [ISO]
- circadian rhythm [IEP, ISO]
- lactation [ISO]
- lung epithelium development [ISO]
- lung saccule development [ISO]
- mammary gland development [ISO]
- memory [ISO]
- negative regulation of transcription by competitive promoter binding [ISO]
- pituitary gland development [ISO]
- positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [IMP]
- positive regulation of fat cell differentiation [ISO, ISS]
- positive regulation of hormone secretion [ISO]
- positive regulation of lipid biosynthetic process [ISO, ISS]
- positive regulation of multicellular organism growth [ISO]
- positive regulation of osteoclast differentiation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- positive regulation of transcription, DNA-templated [ISO, ISS]
- positive regulation of transforming growth factor beta3 production [IMP]
- protein phosphorylation [ISO]
- protein stabilization [ISO, ISS]
- regulation of apoptotic process [IDA]
- regulation of cell size [ISO]
- regulation of circadian rhythm [IMP]
- regulation of transcription, DNA-templated [ISO]
- response to drug [ISO]
- response to glucagon [ISO, ISS]
- response to organic substance [ISO]
- secretory granule organization [ISO]
- transcription from RNA polymerase II promoter [IMP, ISO]
- transforming growth factor beta receptor signaling pathway [IMP]
Gene Ontology Molecular Function- DNA binding [ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA, ISO]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [ISO]
- cAMP response element binding [ISO]
- double-stranded DNA binding [IDA]
- enzyme binding [ISO]
- histone acetyltransferase binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IMP, ISO, TAS]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- DNA binding [ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA, ISO]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [ISO]
- cAMP response element binding [ISO]
- double-stranded DNA binding [IDA]
- enzyme binding [ISO]
- histone acetyltransferase binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IMP, ISO, TAS]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
UBC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Platelet-derived growth factor BB induces nuclear export and proteasomal degradation of CREB via phosphatidylinositol 3-kinase/Akt signaling in pulmonary artery smooth muscle cells.
Cyclic AMP response element binding protein (CREB) content is diminished in smooth muscle cells (SMCs) in remodeled pulmonary arteries from animals with pulmonary hypertension and in the SMC layers of atherogenic systemic arteries and cardiomyocytes from hypertensive individuals. Loss of CREB can be induced in cultured SMCs by chronic exposure to hypoxia or platelet-derived growth factor BB (PDGF-BB). Here we ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CREB1 UBC | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID