UBC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DUSP1
Gene Ontology Biological Process
- cellular response to hormone stimulus [IEP]
- endoderm formation [IBA]
- inactivation of MAPK activity [ISS]
- intracellular signal transduction [IDA]
- mitotic cell cycle arrest [ISS]
- negative regulation of DNA biosynthetic process [IDA]
- negative regulation of ERK1 and ERK2 cascade [IMP]
- negative regulation of MAP kinase activity [ISO, ISS]
- negative regulation of MAPK cascade [ISS]
- negative regulation of apoptotic process [IMP]
- negative regulation of meiotic cell cycle [ISS]
- peptidyl-threonine dephosphorylation [ISS]
- peptidyl-tyrosine dephosphorylation [ISS]
- positive regulation of apoptotic process [IMP]
- protein dephosphorylation [IDA]
- regulation of mitotic cell cycle spindle assembly checkpoint [ISS]
- response to cAMP [IEP]
- response to calcium ion [IEP]
- response to estradiol [IEP]
- response to glucocorticoid [IEP]
- response to hydrogen peroxide [IEP]
- response to light stimulus [IEP]
- response to organic substance [IEP]
- response to retinoic acid [IEP]
- response to testosterone [IEP]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Osmotic regulation of MG-132-induced MAP-kinase phosphatase MKP-1 expression in H4IIE rat hepatoma cells.
BACKGROUND/AIMS: Proteasome inhibitors such as MG-132 are considered as potential therapeutical tools in different clinical settings. The dual specificity MAP-kinase phosphatase MKP-1 plays a role in balancing signals mediating cell death or survival. Here the effect of cell hydration on MG-132-induced MKP-1 expression was investigated in H4IIE rat hepatoma cells. RESULTS: Hyperosmolarity (405mosmol/l) increased MKP-1 expression by MG-132, which was ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DUSP1 UBC | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID