BCL2L11
Gene Ontology Biological Process
- B cell apoptotic process [IGI]
- B cell homeostasis [IGI, IMP]
- T cell homeostasis [IGI, IMP]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- apoptotic process involved in embryonic digit morphogenesis [IGI]
- cell-matrix adhesion [IMP]
- cellular process regulating host cell cycle in response to virus [IDA]
- developmental pigmentation [IGI]
- ear development [IGI]
- extrinsic apoptotic signaling pathway in absence of ligand [IGI, IMP]
- in utero embryonic development [IGI]
- intrinsic apoptotic signaling pathway in response to DNA damage [IGI, ISO]
- kidney development [IGI]
- leukocyte homeostasis [IGI, IMP]
- lymphocyte homeostasis [IGI, IMP]
- male gonad development [IGI]
- mammary gland development [IMP]
- myeloid cell homeostasis [IGI]
- odontogenesis of dentin-containing tooth [IGI]
- positive regulation of apoptotic process [IGI, IMP, ISO]
- positive regulation of apoptotic process by virus [IDA]
- positive regulation of cell cycle [IMP]
- positive regulation of cell death [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- positive regulation of fibroblast apoptotic process [ISO]
- positive regulation of intrinsic apoptotic signaling pathway [ISO]
- positive regulation of mitochondrial membrane permeability involved in apoptotic process [IGI]
- positive regulation of neuron apoptotic process [IDA]
- positive regulation of protein homooligomerization [ISO]
- positive regulation of release of cytochrome c from mitochondria [ISO]
- post-embryonic development [IGI]
- post-embryonic organ morphogenesis [IMP]
- regulation of apoptotic process [IGI]
- regulation of developmental pigmentation [IGI]
- regulation of organ growth [IMP]
- response to endoplasmic reticulum stress [IDA, ISO]
- spermatogenesis [IGI]
- spleen development [IGI]
- thymocyte apoptotic process [IGI]
- thymus development [IGI]
- tube formation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
YWHAB
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function.
Bim, the Bcl-2 interacting mediator of cell death, is a member of the BH3-only family of pro-apoptotic proteins. Recent studies have demonstrated that the apoptotic activity of Bim can be regulated through a post-translational mechanism whereby ERK phosphorylation serves as a signal for Bim ubiquitination and proteasomal degradation. In this report, we investigated the signaling pathways leading to Bim phosphorylation ... [more]
Throughput
- Low Throughput
Ontology Terms
- pro-b-lymphocyte cell line (BTO:0003103)
Additional Notes
- interaction occurred between natively expressed in BaF3 pro-B cell line treated with ILN-3
Curated By
- BioGRID