BAIT
NTRK1
Trk
neurotrophic tyrosine kinase, receptor, type 1
GO Process (42)
GO Function (9)
GO Component (13)
Gene Ontology Biological Process
- B cell differentiation [ISO]
- Sertoli cell development [IMP]
- aging [IEP]
- axon guidance [IMP]
- axonogenesis involved in innervation [ISO, ISS]
- cellular response to growth factor stimulus [IDA]
- cellular response to nerve growth factor stimulus [IDA]
- cellular response to nicotine [IDA]
- detection of mechanical stimulus involved in sensory perception of pain [IMP]
- detection of temperature stimulus involved in sensory perception of pain [IMP]
- developmental programmed cell death [IDA]
- learning or memory [IMP]
- mechanoreceptor differentiation [ISO]
- negative regulation of cell proliferation [ISO, ISS]
- negative regulation of neuron apoptotic process [IMP, ISO]
- negative regulation of neuron death [IDA]
- nerve growth factor signaling pathway [IDA, ISO]
- nervous system development [ISO]
- neurotrophin TRK receptor signaling pathway [ISO, ISS]
- olfactory nerve development [IEP]
- peptidyl-tyrosine phosphorylation [IDA, ISO, ISS]
- positive regulation of ERK1 and ERK2 cascade [ISO, ISS]
- positive regulation of NF-kappaB transcription factor activity [ISO, ISS]
- positive regulation of Ras GTPase activity [ISO, ISS]
- positive regulation of Ras protein signal transduction [ISO, ISS]
- positive regulation of angiogenesis [ISO]
- positive regulation of neuron projection development [ISO, ISS]
- positive regulation of programmed cell death [IDA]
- positive regulation of synaptic transmission, glutamatergic [IMP]
- protein autophosphorylation [IDA, ISO]
- protein phosphorylation [ISO, ISS]
- response to activity [IDA]
- response to axon injury [IEP]
- response to drug [IDA]
- response to electrical stimulus [IDA]
- response to ethanol [IEP]
- response to hydrostatic pressure [IEP]
- response to nicotine [IDA]
- response to nutrient levels [IDA]
- response to radiation [IEP]
- sensory perception of pain [IMP]
- sympathetic nervous system development [ISO, ISS]
Gene Ontology Molecular Function- ephrin receptor binding [IPI]
- kinase binding [IPI]
- nerve growth factor binding [IDA, ISO, ISS]
- nerve growth factor receptor activity [ISO, ISS]
- neurotrophin p75 receptor binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [ISO, ISS]
- protein tyrosine kinase activity [IDA]
- transmembrane receptor protein tyrosine kinase activity [ISO, ISS]
- ephrin receptor binding [IPI]
- kinase binding [IPI]
- nerve growth factor binding [IDA, ISO, ISS]
- nerve growth factor receptor activity [ISO, ISS]
- neurotrophin p75 receptor binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [ISO, ISS]
- protein tyrosine kinase activity [IDA]
- transmembrane receptor protein tyrosine kinase activity [ISO, ISS]
Gene Ontology Cellular Component
Rattus norvegicus
PREY
SHC1
P66shc
SHC (Src homology 2 domain containing) transforming protein 1
GO Process (25)
GO Function (12)
GO Component (5)
Gene Ontology Biological Process
- MAPK cascade [ISO]
- actin cytoskeleton organization [IMP]
- actin cytoskeleton reorganization [ISO]
- activation of MAPK activity [IMP, ISO]
- aging [IPI]
- angiogenesis [ISO]
- cellular response to insulin stimulus [IEP]
- epidermal growth factor receptor signaling pathway [IBA, ISO]
- heart development [ISO]
- insulin receptor signaling pathway [IDA, IMP]
- neuron differentiation [IMP]
- neuron projection development [IMP]
- organ regeneration [IEP]
- positive regulation of DNA replication [IMP]
- positive regulation of smooth muscle cell proliferation [IMP]
- positive regulation of vasoconstriction [IMP]
- regulation of cell proliferation [ISO]
- response to glucocorticoid [IEP]
- response to hydrogen peroxide [IEP]
- response to hypoxia [IEP]
- response to insulin [IEP]
- response to nicotine [IEP]
- response to organic cyclic compound [IEP]
- response to toxic substance [IEP]
- single organismal cell-cell adhesion [ISO]
Gene Ontology Molecular Function- ephrin receptor binding [ISO]
- epidermal growth factor receptor binding [IPI]
- insulin receptor binding [ISO]
- insulin-like growth factor receptor binding [ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphoprotein binding [IPI]
- phosphotyrosine binding [IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- protein kinase binding [IBA]
- protein phosphatase 2A binding [IDA, IPI]
- receptor tyrosine kinase binding [IPI, ISO]
- ephrin receptor binding [ISO]
- epidermal growth factor receptor binding [IPI]
- insulin receptor binding [ISO]
- insulin-like growth factor receptor binding [ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphoprotein binding [IPI]
- phosphotyrosine binding [IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- protein kinase binding [IBA]
- protein phosphatase 2A binding [IDA, IPI]
- receptor tyrosine kinase binding [IPI, ISO]
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling.
Nerve growth factor (NGF) binding to p75(NTR) influences TrkA signaling, yet the molecular mechanism is unknown. We observe that NGF stimulates TrkA polyubiquitination, which was attenuated in p75(-/-) mouse brain. TrkA is a substrate of tumor necrosis factor receptor-associated factor 6 (TRAF6), and expression of K63R mutant ubiquitin or an absence of TRAF6 abrogated TrkA polyubiquitination and internalization. NGF stimulated ... [more]
Mol. Cell Oct. 28, 2005; 20(2);301-12 [Pubmed: 16246731]
Throughput
- Low Throughput
Curated By
- BioGRID