LNX1
Gene Ontology Biological Process
Gene Ontology Molecular Function
ERBB2
Gene Ontology Biological Process
- cell surface receptor signaling pathway [ISO]
- estrus [ISO]
- glial cell differentiation [ISO]
- heart development [IMP]
- motor neuron axon guidance [IMP]
- myelination [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of immature T cell proliferation in thymus [IMP]
- nervous system development [IMP]
- neuromuscular junction development [IMP]
- oligodendrocyte differentiation [IMP]
- peptidyl-tyrosine phosphorylation [ISO]
- peripheral nervous system development [IMP, ISO]
- phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of MAP kinase activity [ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of Ras protein signal transduction [ISO]
- positive regulation of Rho GTPase activity [IMP]
- positive regulation of cell adhesion [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of transcription from RNA polymerase I promoter [ISO]
- positive regulation of transcription from RNA polymerase III promoter [ISO]
- positive regulation of translation [ISO]
- protein autophosphorylation [ISO]
- regulation of ERK1 and ERK2 cascade [ISO]
- regulation of microtubule-based process [ISO]
- response to axon injury [ISO]
- signal transduction [ISO]
- sympathetic nervous system development [ISO]
- transmembrane receptor protein tyrosine kinase signaling pathway [ISO]
- wound healing [ISO]
Gene Ontology Molecular Function- Hsp90 protein binding [ISO]
- RNA polymerase I core binding [ISO]
- glycoprotein binding [ISO]
- growth factor binding [ISO]
- identical protein binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein phosphatase binding [ISO]
- protein tyrosine kinase activity [ISO]
- transmembrane receptor protein tyrosine kinase activity [ISO]
- transmembrane signaling receptor activity [ISO]
- ubiquitin protein ligase binding [ISO]
- Hsp90 protein binding [ISO]
- RNA polymerase I core binding [ISO]
- glycoprotein binding [ISO]
- growth factor binding [ISO]
- identical protein binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein phosphatase binding [ISO]
- protein tyrosine kinase activity [ISO]
- transmembrane receptor protein tyrosine kinase activity [ISO]
- transmembrane signaling receptor activity [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- apical plasma membrane [IDA, ISO]
- basal plasma membrane [ISO]
- basolateral plasma membrane [ISO]
- cytoplasm [IDA, ISO]
- cytoplasmic vesicle [IDA]
- endosome membrane [ISO]
- integral component of membrane [NAS]
- lateral loop [ISO]
- membrane raft [ISO]
- microvillus [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic membrane [ISO]
- receptor complex [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
LNX1 is a perisynaptic Schwann cell specific E3 ubiquitin ligase that interacts with ErbB2.
Non-myelinating perisynaptic Schwann cells wrap motor axon terminals and are required for both functional and structural integrity of the neuromuscular junction. Several lines of evidence indicate that fine-tuning of neuregulin-1/ErbB signaling is critical for maintaining perisynaptic Schwann cells at synapses and that this control may be achieved by the developmental downregulation of the ErbB2 receptor. Here, we identify a direct ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID