BAIT

ESC1

L000004422, YMR219W
Protein localized to the nuclear periphery; involved in telomeric silencing; interacts with PAD4-domain of Sir4p
GO Process (2)
GO Function (0)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

MMS21

NSE2, PSO10, SUMO ligase MMS21, L000001125, YEL019C
SUMO ligase and component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; required for efficient sister chromatid cohesion; mutants are sensitive to methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination; SUMOylates and inhibits Snf1p function
GO Process (1)
GO Function (2)
GO Component (4)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

The SUMO E3 ligase Siz2 exerts a locus dependent effect on gene silencing in yeast.

Nagesh P, Sreesankar E, Hannan A, Shore D, Mishra K

In the yeast Saccharomyces cerevisiae, the two silent mating-type loci and subtelomeric regions are subjected to a well characterized form of gene silencing. Establishment of silencing involves the formation of a distinct chromatin state that is refractory to transcription. This structure is established by the action of Silent Information Regulator proteins (Sir2, Sir3 and Sir4) that bind to nucleosomes and ... [more]

Unknown Feb. 17, 2012; 0(0); [Pubmed: 22345352]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: silencing (APO:0000046)

Additional Notes

  • MMS21 overexpression causes loss of telomeric silencing in esc1 mutant

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
MMS21 ESC1
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-0.4876BioGRID
1974439

Curated By

  • BioGRID