PRKCA
Gene Ontology Biological Process
- cellular calcium ion homeostasis [IMP]
- cellular response to carbohydrate stimulus [IDA]
- central nervous system neuron axonogenesis [ISO]
- chondrocyte differentiation [IDA]
- desmosome assembly [ISO]
- histone H3-T6 phosphorylation [ISO]
- inactivation of MAPK activity [IMP]
- induction of positive chemotaxis [IMP]
- intracellular signal transduction [ISO]
- intrinsic apoptotic signaling pathway [IMP]
- learning or memory [ISO]
- negative regulation of cell proliferation [IGI]
- negative regulation of glial cell apoptotic process [ISO]
- negative regulation of glucose import [IMP]
- negative regulation of heart contraction [ISO]
- negative regulation of insulin receptor signaling pathway [IMP]
- negative regulation of protein kinase activity [IMP]
- negative regulation of protein phosphorylation [IGI, IMP]
- negative regulation of translation [ISO]
- neutrophil chemotaxis [IMP]
- peptidyl-serine autophosphorylation [IDA]
- peptidyl-serine phosphorylation [ISO]
- peptidyl-threonine phosphorylation [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of blood vessel endothelial cell migration [ISO]
- positive regulation of cardiac muscle hypertrophy [ISO]
- positive regulation of cell adhesion [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of dense core granule biogenesis [IMP]
- positive regulation of endothelial cell migration [ISO]
- positive regulation of endothelial cell proliferation [ISO]
- positive regulation of exocytosis [ISO]
- positive regulation of inflammatory response [IMP]
- positive regulation of lipopolysaccharide-mediated signaling pathway [ISO]
- positive regulation of macrophage differentiation [IMP]
- positive regulation of mitotic cell cycle [ISO]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of synapse assembly [ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [IDA, ISO]
- regulation of muscle contraction [IMP]
- regulation of peptidyl-tyrosine phosphorylation [IMP]
- regulation of platelet aggregation [IMP, ISO]
- regulation of receptor-mediated endocytosis [ISO]
- regulation of the force of heart contraction [IMP]
- response to estradiol [ISO]
- response to ethanol [ISO]
- response to interleukin-1 [ISO]
- response to reactive oxygen species [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- apical part of cell [IDA]
- cell [IMP]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- dendrite [IDA]
- endoplasmic reticulum [ISO]
- extracellular vesicular exosome [ISO]
- intracellular [IMP]
- membrane [IDA]
- membrane raft [ISO]
- mitochondrion [IDA, ISO]
- neuron projection [ISO]
- neuronal cell body [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [ISO]
- photoreceptor outer segment [IDA]
- plasma membrane [IDA, ISO]
- protein complex [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Cypher, a striated muscle-restricted PDZ and LIM domain-containing protein, binds to alpha-actinin-2 and protein kinase C.
We have cloned and characterized a novel striated muscle-restricted protein (Cypher) that has two mRNA splice variants, designated Cypher1 and Cypher2. Both proteins contain an amino-terminal PDZ domain. Cypher1, but not Cypher2, contains three carboxyl-terminal LIM domains and an amino acid repeat sequence that exhibits homology to a repeat sequence found in the largest subunit of RNA polymerase II. cypher1 ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID