ISW2
Gene Ontology Biological Process
- chromatin organization involved in regulation of transcription [IMP]
- chromatin remodeling [IDA, IMP]
- chromatin silencing at rDNA [IMP]
- chromatin silencing at telomere [IMP]
- negative regulation of antisense RNA transcription [IGI]
- negative regulation of transcription from RNA polymerase II promoter by pheromones [IMP]
- nucleosome positioning [IDA]
- termination of RNA polymerase II transcription [IGI]
Gene Ontology Molecular Function
SNF2
Gene Ontology Biological Process
- ATP-dependent chromatin remodeling [IDA, IMP]
- DNA-dependent DNA replication [IMP]
- cellular alcohol catabolic process [IMP]
- chromatin remodeling [IGI, IMP]
- double-strand break repair [IMP]
- nucleosome mobilization [IDA, IMP]
- positive regulation of cell adhesion involved in single-species biofilm formation [IMP]
- positive regulation of invasive growth in response to glucose limitation [IMP]
- positive regulation of mating type switching [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IGI, IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation [IMP]
- strand invasion [IMP]
- sucrose catabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- SWI/SNF complex [IDA, IMP]
- nucleus [IDA]
Co-crystal Structure
Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex.
Publication
Disparity in the DNA translocase domains of SWI/SNF and ISW2.
An ATP-dependent DNA translocase domain consisting of seven conserved motifs is a general feature of all ATP-dependent chromatin remodelers. While motifs on the ATPase domains of the yeast SWI/SNF and ISWI families of remodelers are highly conserved, the ATPase domains of these complexes appear not to be functionally interchangeable. We found one reason that may account for this is the ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ISW2 SNF2 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 518759 |
Curated By
- BioGRID