SPRY2
Gene Ontology Biological Process
- branching morphogenesis of an epithelial tube [IMP]
- bud elongation involved in lung branching [IGI]
- cell fate commitment [IGI, IMP]
- establishment of mitotic spindle orientation [IGI]
- inner ear morphogenesis [IGI, IMP]
- lung development [IMP]
- lung growth [IDA]
- lung morphogenesis [IDA]
- negative regulation of ERK1 and ERK2 cascade [IDA, IGI]
- negative regulation of MAP kinase activity [IDA]
- negative regulation of Ras GTPase activity [IDA]
- negative regulation of Ras protein signal transduction [IDA]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of cell proliferation [IDA]
- negative regulation of fibroblast growth factor receptor signaling pathway [IDA, IGI]
- negative regulation of neurotrophin TRK receptor signaling pathway [IDA]
- negative regulation of peptidyl-threonine phosphorylation [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of protein serine/threonine kinase activity [ISO]
- respiratory system development [IDA]
- sensory perception of sound [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SH3KBP1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation.
The ubiquitin ligase Cbl mediates ubiquitination of activated receptor tyrosine kinases (RTKs) and interacts with endocytic scaffold complexes, including CIN85/endophilins, to facilitate RTK endocytosis and degradation. Several mechanisms regulate the functions of Cbl to ensure the fine-tuning of RTK signalling and cellular homeostasis. One regulatory mechanism involves the binding of Cbl to Sprouty2, which sequesters Cbl away from activated epidermal ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID