MDM2
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [ISO]
- establishment of protein localization [ISO]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell cycle arrest [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of protein processing [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- peptidyl-lysine modification [ISO]
- positive regulation of cell cycle [IGI]
- positive regulation of gene expression [ISO]
- positive regulation of mitotic cell cycle [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein export from nucleus [ISO]
- protein catabolic process [IDA]
- protein complex assembly [ISO]
- protein destabilization [ISO]
- protein localization to nucleus [ISO]
- protein ubiquitination [IDA, ISO]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO]
- regulation of protein catabolic process [ISO]
- traversing start control point of mitotic cell cycle [IDA]
Gene Ontology Molecular Function
IGF1R
Gene Ontology Biological Process
- axonogenesis [ISO]
- brain development [IMP]
- epidermis development [IMP]
- establishment of cell polarity [ISO]
- exocrine pancreas development [IMP]
- immune response [ISO]
- inactivation of MAPKK activity [ISO]
- insulin-like growth factor receptor signaling pathway [IC, ISO]
- male sex determination [IMP]
- mammary gland development [IMP]
- negative regulation of MAPK cascade [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of muscle cell apoptotic process [ISO]
- negative regulation of protein kinase B signaling [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IMP]
- neuron projection development [ISO]
- organ morphogenesis [IMP]
- peptidyl-tyrosine autophosphorylation [IDA, ISO]
- phosphatidylinositol-mediated signaling [ISO]
- positive regulation of DNA metabolic process [ISO]
- positive regulation of DNA replication [ISO]
- positive regulation of MAPK cascade [IMP]
- positive regulation of cell migration [ISO]
- positive regulation of cytokinesis [ISO]
- positive regulation of mitosis [IMP]
- positive regulation of protein kinase B signaling [IMP]
- positive regulation of steroid hormone biosynthetic process [ISO]
- prostate gland epithelium morphogenesis [IMP]
- protein autophosphorylation [ISO]
- protein heterooligomerization [ISO]
- protein phosphorylation [IDA]
- protein tetramerization [ISO]
- regulation of JNK cascade [ISO]
Gene Ontology Molecular Function- G-protein alpha-subunit binding [ISO]
- identical protein binding [ISO]
- insulin binding [ISO]
- insulin receptor binding [ISO]
- insulin receptor substrate binding [ISO]
- insulin-like growth factor I binding [ISO]
- insulin-like growth factor binding [IPI, ISO]
- insulin-like growth factor-activated receptor activity [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein binding [IPI]
- protein tyrosine kinase activity [ISO]
- G-protein alpha-subunit binding [ISO]
- identical protein binding [ISO]
- insulin binding [ISO]
- insulin receptor binding [ISO]
- insulin receptor substrate binding [ISO]
- insulin-like growth factor I binding [ISO]
- insulin-like growth factor binding [IPI, ISO]
- insulin-like growth factor-activated receptor activity [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein binding [IPI]
- protein tyrosine kinase activity [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase.
The insulin-like growth factor-1 receptor (IGF-1R) plays important roles in physiological growth and aging as well as promoting several crucial functions in cancer cells. However, the molecular mechanisms involved in expression and down-regulation of IGF-1R are still poorly understood. Here we provide evidence that beta-arrestin, otherwise known to be involved in the regulation of G protein-coupled receptors, serves as an ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID