BAIT

GOS1

L000004085, YHL031C
v-SNARE protein involved in Golgi transport; homolog of the mammalian protein GOS-28/GS28
GO Process (2)
GO Function (1)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Saccharomyces cerevisiae (S288c)
PREY

IKI3

ELP1, KTI7, TOT1, Elongator subunit IKI3, L000003563, YLR384C
Subunit of Elongator complex; Elongator is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
GO Process (2)
GO Function (1)
GO Component (3)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Identification of genes affecting hydrogen sulfide formation in Saccharomyces cerevisiae.

Linderholm AL, Findleton CL, Kumar G, Hong Y, Bisson LF

A screen of the Saccharomyces cerevisiae deletion strain set was performed to identify genes affecting hydrogen sulfide (H(2)S) production. Mutants were screened using two assays: colony color on BiGGY agar, which detects the basal level of sulfite reductase activity, and production of H(2)S in a synthetic juice medium using lead acetate detection of free sulfide in the headspace. A total ... [more]

Appl. Environ. Microbiol. Mar. 01, 2008; 74(5);1418-27 [Pubmed: 18192430]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: chemical compound accumulation (APO:0000095)

Additional Notes

  • double mutants show decreased buildup of hydrogen sulfide in juice compared to a gos1 single mutant

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
IKI3 GOS1
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-0.2659BioGRID
2155635

Curated By

  • BioGRID