MAP3K1
Gene Ontology Biological Process
- JNK cascade [IDA]
- MAPK cascade [IBA]
- activation of JNKK activity [ISO]
- activation of JUN kinase activity [IDA]
- activation of MAPKK activity [IBA]
- apoptotic mitochondrial changes [IMP]
- camera-type eye development [IMP]
- epithelial cell morphogenesis [IMP]
- eyelid development in camera-type eye [IMP]
- positive regulation of actin filament polymerization [IMP]
- protein phosphorylation [IBA]
- protein ubiquitination [ISO]
- regulation of cell migration [IMP]
- transforming growth factor beta receptor signaling pathway [IMP]
- wound healing [IMP]
Gene Ontology Molecular Function- JUN kinase binding [ISO]
- JUN kinase kinase activity [IDA]
- JUN kinase kinase kinase activity [ISO]
- MAP kinase kinase kinase activity [IBA, ISO]
- mitogen-activated protein kinase binding [ISO]
- mitogen-activated protein kinase kinase binding [ISO]
- protein binding [IPI]
- protein kinase activity [ISO]
- protein kinase binding [ISO]
- sphingolipid binding [ISO]
- ubiquitin-protein transferase activity [ISO]
- JUN kinase binding [ISO]
- JUN kinase kinase activity [IDA]
- JUN kinase kinase kinase activity [ISO]
- MAP kinase kinase kinase activity [IBA, ISO]
- mitogen-activated protein kinase binding [ISO]
- mitogen-activated protein kinase kinase binding [ISO]
- protein binding [IPI]
- protein kinase activity [ISO]
- protein kinase binding [ISO]
- sphingolipid binding [ISO]
- ubiquitin-protein transferase activity [ISO]
Gene Ontology Cellular Component
MAP2K7
Gene Ontology Biological Process
- JNK cascade [ISO]
- activation of JUN kinase activity [IDA, ISO]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of protein phosphorylation [ISO]
- protein phosphorylation [IDA, ISO]
- response to UV [ISO]
- response to heat [ISO]
- response to osmotic stress [ISO]
- response to stress [IDA]
- response to tumor necrosis factor [ISO]
- stress-activated MAPK cascade [IDA, ISO]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex.
Cytokine signaling is thought to require assembly of multicomponent signaling complexes at cytoplasmic segments of membrane-embedded receptors, in which receptor-proximal protein kinases are activated. Indeed, CD40, a tumor necrosis factor receptor (TNFR) family member, forms a complex containing adaptor molecules TRAF2 and TRAF3, ubiquitin-conjugating enzyme Ubc13, cellular inhibitor of apoptosis proteins 1 and 2 (c-IAP1/2), IkappaB kinase regulatory subunit IKKgamma ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MAP3K1 MAP2K7 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID