BAIT

PPP1CA

PP-1A, PP1A, PP1alpha, PPP1A
protein phosphatase 1, catalytic subunit, alpha isozyme
Alzheimer's Disease Project
Homo sapiens
PREY

SNCAIP

SYPH1, Sph1
synuclein, alpha interacting protein
Parkinson's Disease Project
UPS Project
Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Protein phosphatase 1α interacting proteins in the human brain.

Esteves SL, Domingues SC, da Cruz E Silva OA, Fardilha M, da Cruz E Silva EF

Abstract Protein Phosphatase 1 (PP1) is a major serine/threonine-phosphatase whose activity is dependent on its binding to regulatory subunits known as PP1 interacting proteins (PIPs), responsible for targeting PP1 to a specific cellular location, specifying its substrate or regulating its action. Today, more than 200 PIPs have been described involving PP1 in panoply of cellular mechanisms. Moreover, several PIPs have ... [more]

OMICS Jan. 01, 2012; 16(1);3-17 [Pubmed: 22321011]

Throughput

  • High Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
SNCAIP PPP1CA
Co-localization
Co-localization

Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.

Low-BioGRID
-
SNCAIP PPP1CA
Two-hybrid
Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Low-BioGRID
-

Curated By

  • BioGRID