BAIT

CIA1

asf1, SPCC663.05c
histone chaperone Cia1
Schizosaccharomyces pombe (972h)
PREY

SIM3

SPBC577.15c
NASP family CENP-A chaperone
GO Process (5)
GO Function (1)
GO Component (4)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)

Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Histone chaperone Asf1 plays an essential role in maintaining genomic stability in fission yeast.

Tanae K, Horiuchi T, Matsuo Y, Katayama S, Kawamukai M

The histone H3-H4 chaperone Asf1 is involved in chromatin assembly (or disassembly), histone exchange, regulation of transcription, and chromatin silencing in several organisms. To investigate the essential functions of Asf1 in Schizosaccharomyces pombe, asf1-ts mutants were constructed by random mutagenesis using PCR. One mutant (asf1-33(ts)) was mated with mutants in 77 different kinase genes to identify synthetic lethal combinations. The ... [more]

PLoS ONE Feb. 01, 2012; 7(1);e30472 [Pubmed: 22291963]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: cell shape (APO:0000051)

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
CIA1 SIM3
Dosage Rescue
Dosage Rescue

A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.

Low-BioGRID
736848
CIA1 SIM3
Dosage Rescue
Dosage Rescue

A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.

Low-BioGRID
635499
CIA1 SIM3
Phenotypic Suppression
Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Low-BioGRID
736847
CIA1 SIM3
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
736849

Curated By

  • BioGRID