GCN5
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PTF2
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
Histone h3 lysine 14 acetylation is required for activation of a DNA damage checkpoint in fission yeast.
Histone lysine acetylation has emerged as a key regulator of genome organization. However, with a few exceptions, the contribution of each acetylated lysine to cellular functions is not well understood because of the limited specificity of most histone acetyltransferases and histone deacetylases. Here we show that the Mst2 complex in Schizosaccharomyces pombe is a highly specific H3 lysine 14 (H3K14) ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: radiation resistance (APO:0000084)
- phenotype: resistance to chemicals (APO:0000087)
- phenotype: uv resistance (APO:0000085)
Additional Notes
- MMS
- bleomycin
- infrared
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GCN5 PTF2 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -6.5026 | BioGRID | 786444 |
Curated By
- BioGRID