BAIT
KCNQ1OT1
Kvlqt1-as, Lit1
KCNQ1 overlapping transcript 1
GO Process (4)
GO Function (2)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
PREY
DNMT1
Cxxc9, Dnmt, Dnmt1o, MCMT, MTase, Met-1, Met1, MommeD2, m.MmuI
DNA methyltransferase (cytosine-5) 1
GO Process (20)
GO Function (15)
GO Component (7)
Gene Ontology Biological Process
- C-5 methylation of cytosine [IDA]
- DNA hypermethylation [ISO]
- DNA methylation [IDA, IMP]
- DNA methylation on cytosine [ISO]
- DNA methylation on cytosine within a CG sequence [ISO]
- S-adenosylhomocysteine metabolic process [ISO]
- S-adenosylmethioninamine metabolic process [ISO]
- S-adenosylmethionine metabolic process [ISO]
- cellular response to amino acid stimulus [IDA]
- cellular response to transforming growth factor beta stimulus [ISO]
- gene silencing [IDA]
- maintenance of DNA methylation [IMP, ISO]
- negative regulation of histone H3-K9 methylation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- positive regulation of gene expression [ISO]
- positive regulation of histone H3-K4 methylation [ISO]
- regulation of cell proliferation [IGI]
- regulation of gene expression [IMP]
- response to antidepressant [ISO]
Gene Ontology Molecular Function- DNA (cytosine-5-)-methyltransferase activity [IDA, ISO]
- DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates [ISO]
- DNA binding [IDA, ISO]
- DNA-methyltransferase activity [ISO]
- RNA binding [IDA]
- chromatin binding [IDA]
- double-stranded DNA binding [ISO]
- estrogen receptor binding [ISO]
- histone deacetylase binding [ISO]
- methyl-CpG binding [IDA, ISO]
- methyltransferase activity [IDA]
- protein binding [IPI]
- protein domain specific binding [ISO]
- unmethylated CpG binding [ISO]
- zinc ion binding [IDA]
- DNA (cytosine-5-)-methyltransferase activity [IDA, ISO]
- DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates [ISO]
- DNA binding [IDA, ISO]
- DNA-methyltransferase activity [ISO]
- RNA binding [IDA]
- chromatin binding [IDA]
- double-stranded DNA binding [ISO]
- estrogen receptor binding [ISO]
- histone deacetylase binding [ISO]
- methyl-CpG binding [IDA, ISO]
- methyltransferase activity [IDA]
- protein binding [IPI]
- protein domain specific binding [ISO]
- unmethylated CpG binding [ISO]
- zinc ion binding [IDA]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Kcnq1ot1 noncoding RNA mediates transcriptional gene silencing by interacting with Dnmt1.
A long noncoding RNA, Kcnq1ot1, regulates the expression of both ubiquitously and tissue-specific imprinted genes within the Kcnq1 domain. However, the functional sequences of the Kcnq1ot1 RNA that mediate lineage-specific imprinting are unknown. Here, we have generated a knockout mouse with a deletion encompassing an 890-bp silencing domain (Delta890) downstream of the Kcnq1ot1 promoter. Maternal transmission of the Delta890 allele ... [more]
Development Aug. 01, 2010; 137(15);2493-9 [Pubmed: 20573698]
Throughput
- Low Throughput
Curated By
- BioGRID