BAIT
MDE4
SPBC6B1.04
monopolin-like complex subunit Mde4
GO Process (4)
GO Function (0)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
BIR1
SPCP31B10.10c, cut17, pbh1, SPCC962.02c
survivin, Bir1
GO Process (7)
GO Function (1)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
A role for metaphase spindle elongation forces in correction of merotelic kinetochore attachments.
During mitosis, equal segregation of chromosomes depends on proper kinetochore-microtubule attachments. Merotelic kinetochore orientation, in which a single kinetochore binds microtubules from both spindle poles [1], is a major cause of chromosome instability [2], which is commonly observed in solid tumors [3, 4]. Using the fission yeast Schizosaccharomyces pombe, we show that a proper force balance between kinesin motors on interpolar ... [more]
Curr. Biol. Feb. 07, 2012; 22(3);225-30 [Pubmed: 22264609]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID