MDE4
Gene Ontology Biological Process
Gene Ontology Cellular Component
ARK1
Gene Ontology Biological Process
- histone H3-S10 phosphorylation involved in chromosome condensation [IDA]
- mitotic cytokinesis [IGI, IMP]
- mitotic sister chromatid segregation [IGI, IMP]
- mitotic spindle assembly checkpoint [IMP]
- protein localization to kinetochore [IMP]
- protein localization to nucleolar rDNA repeats [IMP]
- sister chromatid biorientation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
A role for metaphase spindle elongation forces in correction of merotelic kinetochore attachments.
During mitosis, equal segregation of chromosomes depends on proper kinetochore-microtubule attachments. Merotelic kinetochore orientation, in which a single kinetochore binds microtubules from both spindle poles [1], is a major cause of chromosome instability [2], which is commonly observed in solid tumors [3, 4]. Using the fission yeast Schizosaccharomyces pombe, we show that a proper force balance between kinesin motors on interpolar ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MDE4 ARK1 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 636050 |
Curated By
- BioGRID