SWI6
Gene Ontology Biological Process
- cellular protein localization [IMP]
- chromatin remodeling [NAS]
- chromatin silencing at centromere [IMP]
- chromatin silencing at silent mating-type cassette [IMP]
- chromatin silencing at telomere [IMP]
- chromosome passenger complex localization to kinetochore [NAS]
- donor selection [IMP]
- gene conversion at mating-type locus [IMP]
- mating type switching [IMP]
- mitotic sister chromatid cohesion [IGI]
- negative regulation of reciprocal meiotic recombination [IMP]
- protein localization to chromosome, centromeric region [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CLP1
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [IMP]
- chromosome passenger complex localization to spindle midzone [IMP]
- cytokinesis after mitosis checkpoint [IMP]
- cytokinesis checkpoint [IGI]
- mitotic actomyosin contractile ring maintenance [IGI, IMP]
- negative regulation of G2/M transition of mitotic cell cycle [IMP]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [IGI]
- negative regulation of protein kinase activity [IMP]
- positive regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation [IMP]
- positive regulation of septation initiation signaling [IGI]
- regulation of exit from mitosis [IMP]
- regulation of mitotic sister chromatid segregation [IMP]
- response to mitotic cell cycle spindle assembly checkpoint signaling [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
A role for metaphase spindle elongation forces in correction of merotelic kinetochore attachments.
During mitosis, equal segregation of chromosomes depends on proper kinetochore-microtubule attachments. Merotelic kinetochore orientation, in which a single kinetochore binds microtubules from both spindle poles [1], is a major cause of chromosome instability [2], which is commonly observed in solid tumors [3, 4]. Using the fission yeast Schizosaccharomyces pombe, we show that a proper force balance between kinesin motors on interpolar ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: chromosome segregation (APO:0000208)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SWI6 CLP1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -3.132 | BioGRID | 755738 | |
| CLP1 SWI6 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -3.132 | BioGRID | 789581 | |
| SWI6 CLP1 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 636056 |
Curated By
- BioGRID