A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Altered nuclear tRNA metabolism in La-deleted S. pombe is accompanied by a nutritional stress response involving Atf1p and Pcr1p that is suppressible by Xpo-t/Los1p.

Cherkasova V, Lopez Maury L, Bacikova D, Pridham K, Baehler J, Maraia RJ

Deletion of the sla1+ gene, which encodes a homolog of the human RNA binding protein, La, in S. pombe causes irregularities in tRNA processing with altered distribution of pre-tRNA intermediates. We show using mRNA profiling that cells lacking sla1+ have increased mRNAs from amino acid metabolism (AAM) genes and furthermore, exhibit slow growth in Edinburgh minimal medium (EMM). A subset ... [more]

Unknown Dec. 07, 2011; 0(0); [Pubmed: 22160596]

Throughput

Low Throughput

Ontology Terms

phenotype: utilization of nitrogen source (APO:0000099)

Curated By

BioGRID

Interaction Summary

SLA1

Gene Ontology Biological Process

Gene Ontology Cellular Component

TSC1