BAIT

SLA1

SPAC57A10.10c
La protein homolog
GO Process (3)
GO Function (0)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)
PREY

LOS1

SPBP8B7.09c
karyopherin exportin T Los1 (predicted)
GO Process (2)
GO Function (3)
GO Component (5)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Altered nuclear tRNA metabolism in La-deleted S. pombe is accompanied by a nutritional stress response involving Atf1p and Pcr1p that is suppressible by Xpo-t/Los1p.

Cherkasova V, Lopez Maury L, Bacikova D, Pridham K, Baehler J, Maraia RJ

Deletion of the sla1+ gene, which encodes a homolog of the human RNA binding protein, La, in S. pombe causes irregularities in tRNA processing with altered distribution of pre-tRNA intermediates. We show using mRNA profiling that cells lacking sla1+ have increased mRNAs from amino acid metabolism (AAM) genes and furthermore, exhibit slow growth in Edinburgh minimal medium (EMM). A subset ... [more]

Unknown Dec. 07, 2011; 0(0); [Pubmed: 22160596]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: utilization of nitrogen source (APO:0000099)

Curated By

  • BioGRID