ATXN3
Gene Ontology Biological Process
- actin cytoskeleton organization [ISO]
- cellular response to heat [IMP]
- cellular response to misfolded protein [IMP]
- exploration behavior [IMP]
- intermediate filament cytoskeleton organization [ISO]
- microtubule cytoskeleton organization [ISO]
- misfolded or incompletely synthesized protein catabolic process [IMP]
- monoubiquitinated protein deubiquitination [IDA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
- protein K48-linked deubiquitination [ISO]
- protein K63-linked deubiquitination [ISO]
- proteolysis [ISO]
- regulation of cell-substrate adhesion [IMP, ISO]
- ubiquitin-dependent protein catabolic process [IMP]
Gene Ontology Molecular Function- ATPase binding [ISO]
- Lys48-specific deubiquitinase activity [ISO]
- Lys63-specific deubiquitinase activity [ISO]
- RNA polymerase II regulatory region DNA binding [ISO]
- histone deacetylase activity [ISO]
- identical protein binding [ISO]
- protein binding [IPI]
- ubiquitin protein ligase binding [IPI, ISO]
- ubiquitin thiolesterase activity [IDA]
- ubiquitin-specific protease activity [IDA]
- ATPase binding [ISO]
- Lys48-specific deubiquitinase activity [ISO]
- Lys63-specific deubiquitinase activity [ISO]
- RNA polymerase II regulatory region DNA binding [ISO]
- histone deacetylase activity [ISO]
- identical protein binding [ISO]
- protein binding [IPI]
- ubiquitin protein ligase binding [IPI, ISO]
- ubiquitin thiolesterase activity [IDA]
- ubiquitin-specific protease activity [IDA]
Gene Ontology Cellular Component
STUB1
Gene Ontology Biological Process
- cellular response to misfolded protein [IMP, ISO]
- misfolded or incompletely synthesized protein catabolic process [IMP, ISO]
- positive regulation of chaperone-mediated protein complex assembly [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO, ISS]
- positive regulation of protein ubiquitination [ISO, ISS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP, ISO]
- protein K63-linked ubiquitination [ISO]
- protein autoubiquitination [ISO]
- protein folding [TAS]
- protein maturation [TAS]
- protein polyubiquitination [IDA, ISO]
- protein ubiquitination [TAS]
- regulation of glucocorticoid metabolic process [ISO, ISS]
- ubiquitin-dependent SMAD protein catabolic process [ISO]
- ubiquitin-dependent protein catabolic process [ISO]
Gene Ontology Molecular Function- G-protein coupled receptor binding [ISO]
- Hsp70 protein binding [ISO, ISS, TAS]
- Hsp90 protein binding [ISO, ISS]
- SMAD binding [ISO]
- TPR domain binding [ISO, ISS]
- enzyme binding [ISO]
- heat shock protein binding [TAS]
- kinase binding [ISO]
- misfolded protein binding [ISO]
- protein binding [IPI]
- protein binding, bridging [TAS]
- protein homodimerization activity [IDA]
- ubiquitin protein ligase activity [IDA, ISO]
- ubiquitin protein ligase binding [IPI, ISO]
- ubiquitin-protein transferase activity [ISO, TAS]
- ubiquitin-ubiquitin ligase activity [IDA]
- G-protein coupled receptor binding [ISO]
- Hsp70 protein binding [ISO, ISS, TAS]
- Hsp90 protein binding [ISO, ISS]
- SMAD binding [ISO]
- TPR domain binding [ISO, ISS]
- enzyme binding [ISO]
- heat shock protein binding [TAS]
- kinase binding [ISO]
- misfolded protein binding [ISO]
- protein binding [IPI]
- protein binding, bridging [TAS]
- protein homodimerization activity [IDA]
- ubiquitin protein ligase activity [IDA, ISO]
- ubiquitin protein ligase binding [IPI, ISO]
- ubiquitin-protein transferase activity [ISO, TAS]
- ubiquitin-ubiquitin ligase activity [IDA]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes.
A major hallmark of the polyglutamine diseases is the formation of neuronal intranuclear inclusions of the disease proteins that are ubiquitinated and often associated with various chaperones and proteasome components. But, how the polyglutamine proteins are ubiquitinated and degraded by the proteasomes are not known. Here, we demonstrate that CHIP (C terminus of Hsp70-interacting protein) co-immunoprecipitates with the polyglutamine-expanded huntingtin ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID