BAIT

SORBS2

Argbp2
sorbin and SH3 domain containing 2
GO Process (0)
GO Function (2)
GO Component (4)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Rattus norvegicus
PREY

SH3GL1

SH3P8
SH3-domain GRB2-like 1
GO Process (0)
GO Function (4)
GO Component (1)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Rattus norvegicus

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

The Abl/Arg substrate ArgBP2/nArgBP2 coordinates the function of multiple regulatory mechanisms converging on the actin cytoskeleton.

Cestra G, Toomre D, Chang S, De Camilli P

ArgBP2, and its brain-specific splice variant, nArgBP2, are interactors and substrates of Abl/Arg tyrosine kinases and of the ubiquitin ligase Cbl. They are members of a family of adaptor proteins that colocalize with actin on stress fibers and at cell-adhesion sites, including neuronal synapses. We show here that their NH2-terminal region, which contains a sorbin homology domain domain, interacts with ... [more]

Proc. Natl. Acad. Sci. U.S.A. Feb. 01, 2005; 102(5);1731-6 [Pubmed: 15659545]

Throughput

  • Low Throughput

Curated By

  • BioGRID