BAIT
SORBS2
Argbp2
sorbin and SH3 domain containing 2
GO Process (0)
GO Function (2)
GO Component (4)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
DNM2
DYIIAAB
dynamin 2
GO Process (14)
GO Function (9)
GO Component (19)
Gene Ontology Biological Process
- G-protein coupled receptor internalization [IMP]
- GTP catabolic process [TAS]
- cellular response to X-ray [IEP]
- cilium morphogenesis [IMP]
- endocytosis [TAS]
- macropinocytosis [IMP]
- negative regulation of membrane tubulation [ISO]
- neuron projection morphogenesis [IMP]
- receptor internalization [ISO]
- receptor-mediated endocytosis [IDA, IMP]
- regulation of axon extension [IMP]
- response to light stimulus [IEP]
- spermatogenesis [IEP]
- transferrin transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA, ISO]
- cell junction [IDA]
- centrosome [IDA]
- clathrin-coated endocytic vesicle [IDA]
- coated pit [IDA]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- growth cone [IDA]
- lamellipodium [IDA]
- microtubule [ISO]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- photoreceptor inner segment [ISO]
- plasma membrane [IDA, TAS]
- postsynaptic membrane [ISO, ISS]
- protein complex [IDA]
- ruffle membrane [IDA]
Rattus norvegicus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
The Abl/Arg substrate ArgBP2/nArgBP2 coordinates the function of multiple regulatory mechanisms converging on the actin cytoskeleton.
ArgBP2, and its brain-specific splice variant, nArgBP2, are interactors and substrates of Abl/Arg tyrosine kinases and of the ubiquitin ligase Cbl. They are members of a family of adaptor proteins that colocalize with actin on stress fibers and at cell-adhesion sites, including neuronal synapses. We show here that their NH2-terminal region, which contains a sorbin homology domain domain, interacts with ... [more]
Proc. Natl. Acad. Sci. U.S.A. Feb. 01, 2005; 102(5);1731-6 [Pubmed: 15659545]
Throughput
- Low Throughput
Curated By
- BioGRID