BAIT
SCN2A
NachII, Nav1.2, RII/RIIA, RNSCPIIR, SCN, Scn2a1, Scn2a2, ScpII
sodium channel, voltage-gated, type II, alpha subunit
GO Process (8)
GO Function (4)
GO Component (13)
Gene Ontology Biological Process
- intrinsic apoptotic signaling pathway in response to osmotic stress [ISO]
- membrane depolarization during action potential [IBA]
- myelination [IEP]
- nervous system development [ISO]
- neuron apoptotic process [ISO]
- neuronal action potential [IBA, IDA, TAS]
- sodium ion transmembrane transport [IBA, IDA, ISO]
- sodium ion transport [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- T-tubule [ISO]
- axon [ISO]
- axon initial segment [IDA]
- intercalated disc [ISO]
- intracellular [ISO]
- intrinsic component of plasma membrane [IDA]
- membrane [ISO]
- neuron projection [IDA]
- node of Ranvier [IDA]
- paranode region of axon [ISO]
- plasma membrane [IBA]
- sodium channel complex [IDA]
- voltage-gated sodium channel complex [IDA]
Rattus norvegicus
PREY
NEDD4
AA959633, AL023035, AU019897, E430025J12Rik, Nedd4-1, Nedd4a, mKIAA0093
neural precursor cell expressed, developmentally down-regulated 4
GO Process (16)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- T cell activation [IMP]
- adaptive immune response [IMP]
- blood vessel morphogenesis [IGI, IMP]
- endocardial cushion development [IGI, IMP]
- negative regulation of sodium ion transport [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of vascular endothelial growth factor receptor signaling pathway [IDA]
- neuromuscular junction development [IMP]
- outflow tract morphogenesis [IGI, IMP]
- positive regulation of protein catabolic process [IDA, ISO]
- protein K63-linked ubiquitination [ISO]
- protein monoubiquitination [IDA]
- protein ubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA, IMP]
- regulation of dendrite morphogenesis [IMP, ISO]
- regulation of synapse organization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins.
The voltage-gated Na(+) channels (Na(v)) form a family composed of 10 genes. The COOH termini of Na(v) contain a cluster of amino acids that are nearly identical among 7 of the 10 members. This COOH-terminal sequence, PPSYDSV, is a PY motif known to bind to WW domains of E3 protein-ubiquitin ligases of the Nedd4 family. We recently reported that cardiac ... [more]
Am. J. Physiol., Cell Physiol. Mar. 01, 2005; 288(3);C692-701 [Pubmed: 15548568]
Throughput
- Low Throughput
Curated By
- BioGRID