SCN2A
Gene Ontology Biological Process
- intrinsic apoptotic signaling pathway in response to osmotic stress [ISO]
- membrane depolarization during action potential [IBA]
- myelination [IEP]
- nervous system development [ISO]
- neuron apoptotic process [ISO]
- neuronal action potential [IBA, IDA, TAS]
- sodium ion transmembrane transport [IBA, IDA, ISO]
- sodium ion transport [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- T-tubule [ISO]
- axon [ISO]
- axon initial segment [IDA]
- intercalated disc [ISO]
- intracellular [ISO]
- intrinsic component of plasma membrane [IDA]
- membrane [ISO]
- neuron projection [IDA]
- node of Ranvier [IDA]
- paranode region of axon [ISO]
- plasma membrane [IBA]
- sodium channel complex [IDA]
- voltage-gated sodium channel complex [IDA]
NEDD4
Gene Ontology Biological Process
- T cell activation [IMP]
- adaptive immune response [IMP]
- blood vessel morphogenesis [IGI, IMP]
- endocardial cushion development [IGI, IMP]
- negative regulation of sodium ion transport [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of vascular endothelial growth factor receptor signaling pathway [IDA]
- neuromuscular junction development [IMP]
- outflow tract morphogenesis [IGI, IMP]
- positive regulation of protein catabolic process [IDA, ISO]
- protein K63-linked ubiquitination [ISO]
- protein monoubiquitination [IDA]
- protein ubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA, IMP]
- regulation of dendrite morphogenesis [IMP, ISO]
- regulation of synapse organization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins.
The voltage-gated Na(+) channels (Na(v)) form a family composed of 10 genes. The COOH termini of Na(v) contain a cluster of amino acids that are nearly identical among 7 of the 10 members. This COOH-terminal sequence, PPSYDSV, is a PY motif known to bind to WW domains of E3 protein-ubiquitin ligases of the Nedd4 family. We recently reported that cardiac ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID