RRM1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
KAT5
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [ISO]
- cellular response to estradiol stimulus [ISO]
- double-strand break repair [ISO]
- histone acetylation [ISO]
- negative regulation of interleukin-2 production [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IGI, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- regulation of transcription, DNA-templated [IDA]
- response to ionizing radiation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase.
A balanced deoxyribonucleotide (dNTP) supply is essential for DNA repair. Here, we found that ribonucleotide reductase (RNR) subunits RRM1 and RRM2 accumulated very rapidly at damage sites. RRM1 bound physically to Tip60. Chromatin immunoprecipitation analyses of cells with an I-SceI cassette revealed that RRM1 bound to a damage site in a Tip60-dependent manner. Active RRM1 mutants lacking Tip60 binding failed ... [more]
Throughput
- Low Throughput
Additional Notes
- ChIP
Curated By
- BioGRID