TMF1
Gene Ontology Biological Process
- Leydig cell differentiation [IMP]
- acrosome assembly [IMP]
- cellular response to organic cyclic compound [IMP]
- defense response to bacterium [IMP]
- luteinizing hormone secretion [IMP]
- male gonad development [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of gene expression [IMP]
- positive regulation of cytokine production [IMP]
- positive regulation of testosterone secretion [IMP]
- regulation of proteasomal protein catabolic process [IDA]
- sperm motility [IMP]
- spermatid development [IMP]
- spermatid nucleus differentiation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
UBC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
TMF/ARA160 is a BC-box-containing protein that mediates the degradation of Stat3.
TMF/ARA160 is a Golgi resident protein whose cellular functions have not been conclusively revealed. Herein we show that TMF/ARA160 can direct the proteasomal degradation of the key cell growth regulator - Stat3. TMF/ARA160 was dispersed in the cytoplasm of myogenic C2C12 cells that were grown under low-serum conditions. The cytoplasmic distribution of TMF/ARA160 was accompanied by its transient association with ... [more]
Throughput
- Low Throughput
Additional Notes
- #LPPI
- Likely protein-protein interaction
Curated By
- BioGRID