IRS1
Gene Ontology Biological Process
- cellular response to insulin stimulus [ISO]
- insulin receptor signaling pathway [IDA, ISO]
- insulin secretion [ISO]
- insulin-like growth factor receptor signaling pathway [ISO, ISS]
- lipid catabolic process [ISO]
- mammary gland development [ISO]
- negative regulation of insulin receptor signaling pathway [IMP]
- negative regulation of insulin secretion [IMP, ISO]
- negative regulation of somatostatin secretion [IMP]
- phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of fatty acid beta-oxidation [ISO]
- positive regulation of glucagon secretion [IMP]
- positive regulation of glucose import [ISO]
- positive regulation of glucose import in response to insulin stimulus [ISO]
- positive regulation of glucose metabolic process [ISO]
- positive regulation of glycogen biosynthetic process [ISO]
- positive regulation of insulin receptor signaling pathway [IMP]
- positive regulation of mesenchymal cell proliferation [ISO]
- positive regulation of phosphatidylinositol 3-kinase activity [IDA, ISO]
- positive regulation of phosphorylation [IDA]
- protein heterooligomerization [IDA]
- protein kinase B signaling [ISO]
- protein localization to nucleus [ISO]
- regulation of gene expression [ISO]
- response to caffeine [IDA]
- response to insulin [ISO]
- response to peptide hormone [IDA]
Gene Ontology Molecular Function- SH2 domain binding [IPI]
- insulin receptor binding [IMP, ISO, ISS]
- insulin-like growth factor receptor binding [IPI, ISO, ISS]
- phosphatidylinositol 3-kinase binding [IDA, IMP, IPI, ISO]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase C binding [IPI]
- protein kinase binding [IPI, ISO]
- signal transducer activity [IBA]
- transmembrane receptor protein tyrosine kinase adaptor activity [IMP]
- SH2 domain binding [IPI]
- insulin receptor binding [IMP, ISO, ISS]
- insulin-like growth factor receptor binding [IPI, ISO, ISS]
- phosphatidylinositol 3-kinase binding [IDA, IMP, IPI, ISO]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase C binding [IPI]
- protein kinase binding [IPI, ISO]
- signal transducer activity [IBA]
- transmembrane receptor protein tyrosine kinase adaptor activity [IMP]
Gene Ontology Cellular Component
UBC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1.
beta-arrestin-1 is an adaptor protein that mediates agonist-dependent internalization and desensitization of G-protein-coupled receptors (GPCRs) and also participates in the process of heterologous desensitization between receptor tyrosine kinases and GPCR signaling. In the present study, we determined whether beta-arrestin-1 is involved in insulin-induced insulin receptor substrate 1 (IRS-1) degradation. Overexpression of wild-type (WT) beta-arrestin-1 attenuated insulin-induced degradation of IRS-1, leading ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID